Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 2/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | TTR | P02766 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4261268 | 0.79 | ACVR1 (0.42) | — | |
| SCHEMBL16338929 | 0.75 | PTGER4 (0.43) | TTR | |
| SCHEMBL16338928 | 0.74 | CCR5 (0.32) | TTR | |
| SCHEMBL18914011 | 0.65 | HCAR2 (0.46) | — | |
| SCHEMBL6577587 | 0.60 | GABRP (0.42) | — | |
| SCHEMBL15152162 | 0.59 | MEN1 (0.45) | TTR | |
| SCHEMBL6138291 | 0.59 | OPRM1 (0.35) | — | |
| SCHEMBL31118132 | 0.59 | HCAR2 (0.41) | — | |
| Hydrochloric Acid SCHEMBL11682177 | 0.59 | GABRP (0.41) | — | |
| SCHEMBL30686350 | 0.57 | LATS1 (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8921555-B2 | Substituted-1,3,8-triazaspiro[4.5]decane-2,4-diones | MERCK SHARP & DOHME CORP. (US) | 2014-12-30 | — | — | US | disclosed |