Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | FAAH | O00519 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 2/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1703971 | 0.88 | ALDH1A1 (0.51) | KDM4EFAAHPOLBKMT2AMEN1 | |
| SCHEMBL1632683 | 0.82 | KDM4E (0.48) | KDM4EFAAHPOLBKMT2AMEN1 | |
| SCHEMBL1703908 | 0.78 | ALDH1A1 (0.43) | KDM4EPOLBKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL1631552 | 0.77 | CHRM3 (0.40) | DRD4 | |
| SCHEMBL2007650 | 0.76 | POLB (0.39) | KDM4EPOLBKMT2AMEN1ALDH1A1 | |
| SCHEMBL5619307 | 0.75 | OPRM1 (0.40) | SMN1; SMN2ALDH1A1CYP2D6 | |
| SCHEMBL1188920 | 0.74 | MEN1 (0.48) | KDM4EKMT2AMEN1SMN1; SMN2TDP1 | |
| SCHEMBL3047497 | 0.73 | KDM4E (0.71) | KDM4EFAAHPOLBKMT2AMEN1 | |
| SCHEMBL14813579 | 0.73 | GAA (0.50) | KDM4EPOLBKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL1704166 | 0.70 | KDM4E (0.40) | KDM4EPOLBKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932247-B2 | M3 muscarinic acetylcholine receptor antagonists | GLAXO GROUP LIMITED (GB) | 2011-04-26 | — | — | US | disclosed |