Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1703971 | 0.77 | ALDH1A1 (0.51) | POLBALDH1A1KDM4ECYP2D6CYP3A4 | |
| SCHEMBL2010193 | 0.76 | OPRD1 (0.37) | POLBALDH1A1KDM4EGAA | |
| SCHEMBL1703908 | 0.76 | ALDH1A1 (0.43) | POLBALDH1A1KDM4ETSHRCYP2D6 | |
| SCHEMBL1633895 | 0.76 | KDM4E (0.51) | POLBALDH1A1KDM4ECYP2D6CYP3A4 | |
| SCHEMBL1188920 | 0.74 | MEN1 (0.48) | ALDH1A1KDM4EGAAMEN1KMT2A | |
| SCHEMBL5619307 | 0.73 | OPRM1 (0.40) | ALDH1A1TSHRCYP2D6 | |
| SCHEMBL1704166 | 0.70 | KDM4E (0.40) | POLBALDH1A1KDM4EGAAMEN1 | |
| SCHEMBL14813579 | 0.69 | GAA (0.50) | POLBALDH1A1KDM4EGAATSHR | |
| SCHEMBL5743699 | 0.68 | ALOX15 (0.39) | GAAKMT2A | |
| SCHEMBL18011026 | 0.68 | ALOX15 (0.39) | GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7964602-B2 | Biaryl compounds useful as agonists of the Gpr38 receptor | GLAXO GROUP LIMITED (GB) | 2011-06-21 | — | — | US | disclosed |