Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 5/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | F13A1 | P00488 | 1/20 | 0.36 |
| ▸ | TGM2 | P21980 | 1/20 | 0.36 |
| ▸ | TGM1 | P22735 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1704163 | 0.75 | PDK1 (0.44) | F13A1TGM2TGM1HDAC3HDAC1 | |
| SCHEMBL1704594 | 0.74 | MLNR (0.42) | KDM4EKMT2APOLBALDH1A1 | |
| SCHEMBL4192349 | 0.74 | KMT2A (0.41) | KDM4EKMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL4192341 | 0.74 | KMT2A (0.41) | KDM4EKMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL1703971 | 0.74 | ALDH1A1 (0.51) | KDM4EKMT2APOLBMEN1NPC1 | |
| SCHEMBL1703908 | 0.72 | ALDH1A1 (0.43) | KDM4EKMT2APOLBMEN1LMNA | |
| SCHEMBL2007650 | 0.70 | POLB (0.39) | KDM4EGAAKMT2APKMPOLB | |
| SCHEMBL1633895 | 0.70 | KDM4E (0.51) | KDM4EKMT2APOLBMEN1LMNA | |
| SCHEMBL1411068 | 0.68 | CA12 (0.48) | KDM4EGAANPC1RAB9AALDH1A1 | |
| SCHEMBL5222801 | 0.68 | ROCK2 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441763-A1 | Benzylpiperazine derivatives useful for the treatment of gastrointestinal disorders | Glaxo Group Limited (GB) | 2012-04-18 | — | — | EP | disclosed |