Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.39 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | MGAM | O43451 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SI | P14410 | 1/20 | 0.37 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.37 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.37 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.36 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.35 |
| ▸ | CES2 | O00748 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19122395 | 0.84 | ALDH1A1 (0.42) | ALDH1A1NPSR1GLO1LMNAHSD17B10 | |
| SCHEMBL22213926 | 0.81 | MAPT (0.34) | ALDH1A1NPSR1GLO1LMNAHSD17B10 | |
| SCHEMBL28620279 | 0.81 | MAPT (0.34) | ALDH1A1NPSR1GLO1LMNAHSD17B10 | |
| SCHEMBL4574752 | 0.79 | ALDH1A1 (0.42) | ALDH1A1NPSR1GLO1LMNAHSD17B10 | |
| SCHEMBL4918392 | 0.78 | FAAH (0.43) | ALDH1A1NPSR1GLO1LMNAHSD17B10 | |
| SCHEMBL9546127 | 0.78 | ALDH1A1 (0.44) | ALDH1A1NPSR1GLO1LMNAHSD17B10 | |
| SCHEMBL8785380 | 0.78 | NPSR1 (0.42) | ALDH1A1NPSR1GLO1LMNAFAAH | |
| SCHEMBL17397711 | 0.77 | CYP2C9 (0.45) | ALDH1A1NPSR1GLO1LMNAFAAH | |
| SCHEMBL17397712 | 0.77 | CYP2C9 (0.45) | ALDH1A1NPSR1GLO1LMNAFAAH | |
| SCHEMBL25398009 | 0.76 | TET2 (0.38) | ALDH1A1TSHREGLN1GPR35MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2713736-B1 | NOVEL IMMUNE SYSTEM MODULATORS | JANUS BIOTHERAPEUTICS INC (US) | 2023-08-02 | — | — | EP | disclosed |
| CN-113912535-A | Preparation method of 6-chloro-4-trifluoromethyl-3-cyanopyridine | 新发药业有限公司 | 2022-01-11 | — | — | CN | disclosed |
| US-10117875-B2 | Immune system modulators | JANUS BIOTHERAPEUTICS, INC. (US) | 2018-11-06 | — | — | US | disclosed |
| US-20170224699-A1 | NOVEL IMMUNE SYSTEM MODULATORS | Wilmer Cutler Pickering Hale and Dorr LLP | 2017-08-10 | — | — | US | disclosed |
| US-9637489-B2 | Immune system modulators | JANUS BIOTHERAPEUTICS, INC. (US) | 2017-05-02 | — | — | US | disclosed |
| US-9359361-B2 | Immune system modulators | JANUS BIOTHERAPEUTICS, INC. (US) | 2016-06-07 | — | — | US | disclosed |
| CN-103228668-B | Antidiabetic enolic glycoside of phenylpyruvic acid | ZADEC APS (DK) | 2016-04-27 | — | — | CN | disclosed |
| US-20160074403-A1 | NOVEL IMMUNE SYSTEM MODULATORS | Wilmer Cutler Pickering Hale and Dorr LLP | 2016-03-17 | — | — | US | disclosed |
| US-9126996-B2 | Immune system modulators | JANUS BIOTHERAPEUTICS, INC. (US) | 2015-09-08 | — | — | US | disclosed |
| US-20140221646-A1 | NOVEL IMMUNE SYSTEM MODULATORS | JANUS BIOTHERAPEUTICS, INC. (US) | 2014-08-07 | — | — | US | disclosed |
| US-20040162321-A1 | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2004-08-19 | — | — | US | disclosed |
| WO-2004063163-A1 | 1-PROPANOL AND 1-PROPYLAMINE DERIVATIVES AND THEIR USE AS GLUCOCORTICOID LIGANDS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2004-07-29 | — | — | WO | disclosed |
| US-20040029932-A1 | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2004-02-12 | — | — | US | disclosed |
| US-20040023999-A1 | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2004-02-05 | — | — | US | disclosed |
| US-20040010148-A1 | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2004-01-15 | — | — | US | disclosed |
| US-20040010020-A1 | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2004-01-15 | — | — | US | disclosed |
| WO-2003104195-A1 | 4-(ARYL OR HETEROARYL) -2-BUTYLAMINE DERIVATIVES AND THEIR USE AS GLUCOCORTICOID LIGANS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2003-12-18 | — | — | WO | disclosed |
| WO-2003101932-A2 | GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2003-12-11 | — | — | WO | disclosed |
| WO-2003082787-A1 | GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2003-10-09 | — | — | WO | disclosed |
| WO-2003082280-A1 | GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2003-10-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040010020-A1 | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof | NR3C1, NR3C2, MC2R | ALDH1A1 2921/4885NPSR1 356/4885GLO1 1665/4885 |
| US-20140221646-A1 | NOVEL IMMUNE SYSTEM MODULATORS | HLA-DRB1, CD47, MYD88 | ALDH1A1 2143/4885NPSR1 874/4885GLO1 3575/4885 |
| US-20040029932-A1 | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof | NR3C1, NR3C2, MC2R | ALDH1A1 2659/4885NPSR1 370/4885GLO1 1180/4885 |
| US-20040023999-A1 | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof | NR3C1, NR3C2, MC2R | ALDH1A1 2659/4885NPSR1 370/4885GLO1 1180/4885 |
| US-20040162321-A1 | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof | NR3C1, NR3C2, MC2R | ALDH1A1 2975/4885NPSR1 316/4885GLO1 1593/4885 |
| US-10117875-B2 | Immune system modulators | HLA-DRB1, CD47, MYD88 | ALDH1A1 1649/4885NPSR1 921/4885GLO1 3328/4885 |
| US-20040010148-A1 | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof | NR3C1, NR3C2, MC2R | ALDH1A1 2749/4885NPSR1 320/4885GLO1 1474/4885 |
| US-20160074403-A1 | NOVEL IMMUNE SYSTEM MODULATORS | HLA-DRB1, CD47, MYD88 | ALDH1A1 2143/4885NPSR1 874/4885GLO1 3575/4885 |
| US-20170224699-A1 | NOVEL IMMUNE SYSTEM MODULATORS | HLA-DRB1, CD47, MYD88 | ALDH1A1 2143/4885NPSR1 874/4885GLO1 3575/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.