Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 7/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.40 |
| ▸ | HTT | P42858 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | NCOA1 | Q15788 | 3/20 | 0.40 |
| ▸ | NCOA3 | Q9Y6Q9 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | XBP1 | P17861 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.35 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18195530 | 0.83 | ALDH1A1 (0.37) | LMNASMN1; SMN2POLBKDM4EALDH1A1 | |
| SCHEMBL27158634 | 0.75 | SMN1; SMN2 (0.40) | LMNASMN1; SMN2HTTMAPTPOLB | |
| SCHEMBL3559919 | 0.74 | ALDH1A1 (0.40) | LMNASMN1; SMN2POLBKDM4EALDH1A1 | |
| SCHEMBL28257885 | 0.74 | NOS2 (0.46) | LMNASMN1; SMN2HTTMAPTKDM4E | |
| SCHEMBL30751791 | 0.74 | ALDH1A1 (0.40) | LMNASMN1; SMN2POLBKDM4EALDH1A1 | |
| SCHEMBL24146604 | 0.74 | KMT2A (0.33) | LMNASMN1; SMN2HTTMAPTNCOA1 | |
| SCHEMBL15849385 | 0.72 | NOS2 (0.40) | LMNASMN1; SMN2HTTMAPTKDM4E | |
| SCHEMBL15691383 | 0.72 | ALDH1A1 (0.39) | LMNASMN1; SMN2POLBKDM4EALDH1A1 | |
| Ammonia Solution, Strong SCHEMBL28593822 | 0.72 | NOS3 (0.45) | LMNASMN1; SMN2HTTMAPTKDM4E | |
| SCHEMBL677194 | 0.71 | L3MBTL1 (0.45) | LMNASMN1; SMN2HTTMAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140378474-A1 | 5-membered heteroarylcarboxamide derivatives as plasma kallikrein inhibitors | NOVARTIS AG (CH) | 2014-12-25 | — | — | US | disclosed |
| US-20140378474-A1 | 5-membered heteroarylcarboxamide derivatives as plasma kallikrein inhibitors | NOVARTIS AG (CH) | 2014-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140378474-A1 | 5-membered heteroarylcarboxamide derivatives as plasma kallikrein inhibitors | KLKB1, KLK5, KLK1 | LMNA 1206/4885SMN1; SMN2 4824/4885HTT 4557/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.