SCHEMBL677194

SCHEMBL677194

Cc1ccnc(Cl)c1C#N

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.45
BCL6 P41182 4/20 0.40
KMT2A Q03164 4/20 0.39
MEN1 O00255 2/20 0.39
ALDH1A1 P00352 6/20 0.39
LMNA P02545 2/20 0.39
KDM4E B2RXH2 2/20 0.39
TDP1 Q9NUW8 1/20 0.39
NTRK1 P04629 1/20 0.39
PIM1 P11309 1/20 0.39
ACVR1 Q04771 1/20 0.39
HPGD P15428 2/20 0.38
RAB9A P51151 2/20 0.38
NPC1 O15118 1/20 0.38
POLB P06746 1/20 0.38
RECQL P46063 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
CYP1A2 P05177 3/20 0.38
CYP2C19 P33261 3/20 0.38
CYP2C9 P11712 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13538542 0.79 CCR1 (0.35) L3MBTL1LMNASMN1; SMN2CCR1CCR5
SCHEMBL1702773 0.78 LRRK2 (0.42) L3MBTL1BCL6KMT2AMEN1ALDH1A1
SCHEMBL30751791 0.78 ALDH1A1 (0.40) KMT2AMEN1ALDH1A1LMNAKDM4E
SCHEMBL3559919 0.78 ALDH1A1 (0.40) KMT2AMEN1ALDH1A1LMNAKDM4E
SCHEMBL30072681 0.78 LRRK2 (0.42) L3MBTL1BCL6KMT2AMEN1ALDH1A1
SCHEMBL15691383 0.77 ALDH1A1 (0.39) KMT2AMEN1ALDH1A1LMNAKDM4E
SCHEMBL5805842 0.76 ALDH1A1 (0.59) L3MBTL1BCL6KMT2AMEN1ALDH1A1
SCHEMBL5802874 0.75 KCNMA1 (0.40) L3MBTL1BCL6KMT2AMEN1ALDH1A1
SCHEMBL17212756 0.75 PRKACA (0.44) L3MBTL1BCL6KMT2AMEN1ALDH1A1
SCHEMBL1721807 0.75 PSMD14 (0.40) KMT2AMEN1ALDH1A1LMNAKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 148 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105859614-B Method for preparing 2-chloro-3-cyano-4-methylpyridine 盐城迪赛诺制药有限公司 2020-05-26 CN claimed
WO-2016118586-A1 LOWCOST, HIGH YIELD SYNTHESIS OF NEVIRAPINE VIRGINIA COMMONWEALTH UNIVERSITY (US) 2016-07-28 WO claimed
EP-1064265-B8 SYNTHESIS OF 3-AMINO-2-CHLORO-4-METHYLPYRIDINE FROM MALONONITRILE AND ACETONE BOEHRINGER INGELHEIM PHARMA (US) 2004-10-13 EP claimed
EP-1326836-B1 PROCESS FOR MAKING 3-AMINO-2-CHLORO-4-METHYLPYRIDINE BOEHRINGER INGELHEIM CHEMICALS (US) 2004-05-06 EP claimed
EP-1064265-B1 SYNTHESIS OF 3-AMINO-2-CHLORO-4-METHYLPYRIDINE FROM MALONONITRILE AND ACETONE BOEHRINGER INGELHEIM PHARMA (US) 2004-04-14 EP claimed
EP-1326836-A1 PROCESS FOR MAKING 3-AMINO-2-CHLORO-4-METHYLPYRIDINE Boehringer Ingelheim Chemicals, Inc. (US) 2003-07-16 EP claimed
EP-1064265-A4 SYNTHESIS OF 3-AMINO-2-CHLORO-4-METHYLPYRIDINE FROM MALONONITRILE AND ACETONE BOEHRINGER INGELHEIM PHARMA (US) 2003-02-12 EP claimed
US-6399781-B1 A KEY INTERMEDIATE IN THE PRODUCTION OF NEVIRAPINE, STARTING BY REACTING ACETYLACETALDEHYDE DIMETHYL ACETAL WITH MALONONITRILE, IN THE PRESENCE OF AN AMMONIUM SALT CATALYST BOEHRINGER INGELHEIM CHEMICALS, INC. 2002-06-04 US claimed
US-20020052507-A1 Process for making 3-amino-2-chloro-4-methylpyridine BOEHRINGER INGELHEIM CHEMICALS, INC. 2002-05-02 US claimed
WO-2002030901-A1 PROCESS FOR MAKING 3-AMINO-2-CHLORO-4-METHYLPYRIDINE BOEHRINGER INGELHEIM CHEMICALS, INC. (US) 2002-04-18 WO claimed
EP-1064265-A1 SYNTHESIS OF 3-AMINO-2-CHLORO-4-METHYLPYRIDINE FROM MALONONITRILE AND ACETONE BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) 2001-01-03 EP claimed
US-6111112-A Synthesis of 3-amino-2-chloro-4-methylpyridine from malononitrile and acetone BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) 2000-08-29 US claimed
WO-2000043365-A1 SYNTHESIS OF 3-AMINO-2-CHLORO-4-METHYLPYRIDINE FROM MALONONITRILE AND ACETONE BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) 2000-07-27 WO claimed
EP-4743462-A1 COMPOUNDS COMPRISING A NAPHTHYRIDINE OR PYRIDOPYRIMIDINE CORE AS PTC READ-THROUGH AGENTS Tay Therapeutics Limited (GB) 2026-05-20 EP disclosed
EP-4633735-A1 INHIBITORY COMPOUNDS Storm Therapeutics Ltd (GB) 2025-10-22 EP disclosed
EP-3820860-B1 PYRIDAZINE COMPOUNDS FOR INHIBITING NAV1.8 LIEBER INST INC (US) 2025-10-15 EP disclosed
CN-1312807-A Inhibitors of glycogen synthase kinase 3 CHIRON CORP (US) 2001-09-12 CN disclosed
EP-1064265-A1 SYNTHESIS OF 3-AMINO-2-CHLORO-4-METHYLPYRIDINE FROM MALONONITRILE AND ACETONE BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) 2001-01-03 EP disclosed
US-6111112-A Synthesis of 3-amino-2-chloro-4-methylpyridine from malononitrile and acetone BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) 2000-08-29 US disclosed
WO-2000043365-A1 SYNTHESIS OF 3-AMINO-2-CHLORO-4-METHYLPYRIDINE FROM MALONONITRILE AND ACETONE BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) 2000-07-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020052507-A1 Process for making 3-amino-2-chloro-4-methylpyridine MTAP, TPMT, AMPD2 L3MBTL1 2376/4885BCL6 2533/4885KMT2A 205/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.