SCHEMBL16355374

SCHEMBL16355374

c1ccc2cc(-c3c4ccccc4c(-c4ccc5nn(-c6ccncc6)nc5c4)c4ccccc34)ccc2c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK10 P53779 13/20 0.46
MAPK9 P45984 11/20 0.46
MAPK8 P45983 3/20 0.46
KDM4E B2RXH2 3/20 0.39
MEN1 O00255 3/20 0.39
MAPT P10636 3/20 0.39
KMT2A Q03164 3/20 0.39
ALDH1A1 P00352 2/20 0.39
NPC1 O15118 1/20 0.39
STAT1 P42224 1/20 0.39
RAB9A P51151 1/20 0.39
ALOX5 P09917 1/20 0.38
HPGD P15428 2/20 0.37
APAF1 O14727 1/20 0.37
TP53 P04637 1/20 0.37
ALOX15 P16050 1/20 0.37
CASP1 P29466 1/20 0.37
CASP7 P55210 1/20 0.37
HSD17B10 Q99714 1/20 0.37
CYP17A1 P05093 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16355316 0.95 MAPK10 (0.42) MAPK10MAPK9MAPK8KDM4EMEN1
SCHEMBL16355349 0.91 MAPK10 (0.39) MAPK10MAPK9MAPK8ALOX5CYP17A1
SCHEMBL16355367 0.88 GRM5 (0.41) MAPK10MAPK9MAPK8KDM4EMEN1
SCHEMBL15959614 0.88 KDM4E (0.45) KDM4EMEN1MAPTKMT2AALDH1A1
SCHEMBL19529190 0.86 KDM4E (0.44) KDM4EMEN1MAPTKMT2AALDH1A1
SCHEMBL30911067 0.86 CYP11B2 (0.53) KDM4EMEN1MAPTKMT2AALDH1A1
SCHEMBL15949791 0.86 CYP11B2 (0.53) KDM4EMEN1MAPTKMT2AALDH1A1
SCHEMBL17805262 0.86 CYP11B1 (0.50) KDM4EMEN1MAPTKMT2AALDH1A1
SCHEMBL10018423 0.85 CYP11B2 (0.56) MAPK9MAPK8KDM4EMAPTALDH1A1
SCHEMBL10050052 0.84 CYP11B2 (0.54) MAPK9MAPK8KDM4EMAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10593884-B2 Organic electroluminescent device HODOGAYA CHEMICAL CO., LTD. (JP) 2020-03-17 US disclosed
US-20180006235-A1 ORGANIC ELECTROLUMINESCENT DEVICE HODOGAYA CHEMICAL CO., LTD. (JP) 2018-01-04 US disclosed
US-20170346009-A1 ORGANIC ELECTROLUMINESCENT DEVICE SFC CO., LTD. (KR) 2017-11-30 US disclosed
US-20170346009-A1 ORGANIC ELECTROLUMINESCENT DEVICE SFC CO., LTD. (KR) 2017-11-30 US disclosed
US-9123897-B2 Benzotriazole derivatives and organic electroluminescent devices using the derivatives HODOGAYA CHEMICAL CO., LTD. (JP) 2015-09-01 US disclosed
US-9123897-B2 Benzotriazole derivatives and organic electroluminescent devices using the derivatives HODOGAYA CHEMICAL CO., LTD. (JP) 2015-09-01 US disclosed
US-20140374721-A1 NOVEL BENZOTRIAZOLE DERIVATIVES AND ORGANIC ELECTROLUMINESCENT DEVICES USING THE DERIVATIVES HODOGAYA CHEMICAL CO., LTD (JP) 2014-12-25 US disclosed
US-20140374721-A1 NOVEL BENZOTRIAZOLE DERIVATIVES AND ORGANIC ELECTROLUMINESCENT DEVICES USING THE DERIVATIVES HODOGAYA CHEMICAL CO., LTD (JP) 2014-12-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10593884-B2 Organic electroluminescent device AHR, SLC18A1, KCNH1 MAPK10 710/4885MAPK9 679/4885MAPK8 2102/4885
US-20180006235-A1 ORGANIC ELECTROLUMINESCENT DEVICE AHR, SLC18A1, KCNH1 MAPK10 710/4885MAPK9 679/4885MAPK8 2102/4885
US-20170346009-A1 ORGANIC ELECTROLUMINESCENT DEVICE AHR, SLC18A1, ARNT MAPK10 714/4885MAPK9 528/4885MAPK8 1801/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.