Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.47 |
| ▸ | PGR | P06401 | 4/20 | 0.47 |
| ▸ | AR | P10275 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.47 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 5/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.46 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3028086 | 1.00 | CYP19A1 (0.48) | CYP19A1CYP3A4PGRARALDH1A1 | |
| SCHEMBL369752 | 0.81 | CYP3A4 (0.66) | CYP19A1CYP3A4PGRARALDH1A1 | |
| SCHEMBL29882740 | 0.81 | CYP3A4 (0.66) | CYP19A1CYP3A4PGRARALDH1A1 | |
| SCHEMBL18402585 | 0.81 | CYP3A4 (0.66) | CYP19A1CYP3A4PGRARALDH1A1 | |
| SCHEMBL13981881 | 0.81 | CYP3A4 (0.66) | CYP19A1CYP3A4PGRARALDH1A1 | |
| SCHEMBL10896735 | 0.81 | CYP3A4 (0.66) | CYP19A1CYP3A4PGRARALDH1A1 | |
| SCHEMBL1635631 | 0.77 | CYP3A4 (0.44) | CYP19A1CYP3A4PGRARALDH1A1 | |
| SCHEMBL4753154 | 0.76 | ALDH1A1 (0.67) | CYP19A1CYP3A4PGRARALDH1A1 | |
| SCHEMBL4751113 | 0.74 | SERPINA6 (0.67) | CYP19A1CYP3A4PGRARALDH1A1 | |
| SCHEMBL1635637 | 0.73 | ALDH1A1 (0.65) | CYP19A1CYP3A4PGRARALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932382-B2 | Amide substituted heterocylic compound; anticarcinogen; inducing apoptotic cell death, sensitizing cells to inducers of apoptosis | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2011-04-26 | — | — | US | disclosed |
| US-20090082445-A1 | GOSSYPOL CO-CRYSTALS AND THE USE THEREOF | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2009-03-26 | — | — | US | disclosed |
| WO-2008148473-A2 | METHOD FOR THE PRODUCTION OF 17 ALPHA-ACETOXY-6-METHYLENEPREGN-4-ENE-3,20-DIONE, MEDROXYPROGESTERONE ACETATE, AND MEGESTROL ACETATE | BAYER SCHERING PHARMA AG (DE) | 2008-12-11 | — | — | WO | disclosed |
| US-20080269140-A1 | Conformationally Constrained Smac Mimetics and the Uses Thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2008-10-30 | — | — | US | disclosed |
| WO-2002026325-A9 | RESTORATION OF PERTURBED BARRIER FUNCTION BY APPLICATION OF ANTIANDROGENS | UNIV CALIFORNIA (US) | 2003-02-13 | — | — | WO | disclosed |
| WO-2002026325-A2 | RESTORATION OF PERTURBED BARRIER FUNCTION BY APPLICATION OF ANTIANDROGENS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2002-04-04 | — | — | WO | disclosed |
| EP-0479867-A1 | COMPOSITIONS USEFUL AS CONTRACEPTIVES IN MALES. | COHEN MICHAEL (NL) | 1992-04-15 | — | — | EP | disclosed |
| WO-1991000095-A1 | COMPOSITIONS USEFUL AS CONTRACEPTIVES IN MALES | COHEN MICHAEL (NL) | 1991-01-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269140-A1 | Conformationally Constrained Smac Mimetics and the Uses Thereof | BID, API5, BIRC3 | CYP19A1 4669/4885CYP3A4 4804/4885PGR 4426/4885 |
| US-20090082445-A1 | GOSSYPOL CO-CRYSTALS AND THE USE THEREOF | BAX, BCL2, CASP8 | CYP19A1 3440/4885CYP3A4 3951/4885PGR 4476/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.