Sugi Predict

Sugi Predict / Compounds / SCHEMBL16360204

SCHEMBL16360204

SCHEMBL16360204

COc1ccc2c3c(cc(O)c2c1)C1(CC(C)(C)CC(C)(C)C1)c1ccccc1-3

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 2/20 0.38
▸ KMT2A Q03164 2/20 0.38
▸ GAA P10253 1/20 0.38
▸ PDK2 Q15119 5/20 0.36
▸ CDK1 P06493 2/20 0.34
▸ CCNB1 P14635 2/20 0.34
▸ GSK3B P49841 2/20 0.34
▸ CCNB2 O95067 1/20 0.34
▸ GSK3A P49840 1/20 0.34
▸ CDK5 Q00535 1/20 0.34
▸ CDK5R1 Q15078 1/20 0.34
▸ CCNB3 Q8WWL7 1/20 0.34
▸ HSP90AA1 P07900 1/20 0.33
▸ PARP1 P09874 1/20 0.33
▸ AR P10275 2/20 0.32
▸ HDAC4 P56524 2/20 0.32
▸ HDAC2 Q92769 2/20 0.32
▸ HDAC8 Q9BY41 2/20 0.32
▸ MAPT P10636 3/20 0.31
▸ ALDH1A1 P00352 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12424698 0.95 PDK2 (0.38) MEN1KMT2AGAAPDK2CDK1
SCHEMBL22005185 0.91 MEN1 (0.34) MEN1KMT2AGAAPDK2MAPT
SCHEMBL13868641 0.88 HDAC4 (0.40) MEN1KMT2AGAAPDK2HDAC4
SCHEMBL13868651 0.87 PDK2 (0.41) MEN1KMT2AGAAPDK2HDAC4
SCHEMBL26452512 0.86 MAPT (0.33) MEN1KMT2AGAAMAPTALDH1A1
SCHEMBL10293306 0.86 PDK2 (0.34) MEN1KMT2AGAAPDK2GSK3B
SCHEMBL10261681 0.86 PDK2 (0.34) MEN1KMT2AGAAPDK2HSP90AA1
SCHEMBL13868655 0.86 PDK2 (0.34) MEN1KMT2AGAAPDK2GSK3B
SCHEMBL24404156 0.86 PDK2 (0.35) MEN1KMT2AGAAPDK2PARP1
SCHEMBL24404034 0.85 MEN1 (0.41) MEN1KMT2AGAAPDK2CDK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230242808-A1 PHOTOCHROMIC COMPOUND AND CURABLE COMPOSITION CONTAINING THE PHOTOCHROMIC COMPOUND TOKUYAMA CORPORATION (JP) 2023-08-03 — — US disclosed
US-20230242808-A1 PHOTOCHROMIC COMPOUND AND CURABLE COMPOSITION CONTAINING THE PHOTOCHROMIC COMPOUND TOKUYAMA CORPORATION (JP) 2023-08-03 — — US disclosed
US-20220213050-A1 CHROMENE COMPOUND AND PHOTOCHROMIC OPTICAL ARTICLE TOKUYAMA CORPORATION (JP) 2022-07-07 — — US disclosed
US-9643905-B2 Phenylnaphthol derivatives TOKUYAMA CORPORATION (JP) 2017-05-09 — — US disclosed
US-20160130203-A1 NOVEL PHENYLNAPHTHOL DERIVATIVES TOKUYAMA CORPORATION (JP) 2016-05-12 — — US disclosed
EP-3018115-A1 NOVEL PHENYL NAPTHOL DERIVATIVE Tokuyama Corporation (JP) 2016-05-11 — — EP disclosed
WO-2011078030-A1 CHROMENE COMPOUND 株式会社トクヤマ (JP) 2011-06-30 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220213050-A1 CHROMENE COMPOUND AND PHOTOCHROMIC OPTICAL ARTICLE CRY1, CRY2, TRIP13 MEN1 1743/4885KMT2A 2777/4885GAA 4668/4885
US-20160130203-A1 NOVEL PHENYLNAPHTHOL DERIVATIVES AHR, ARL1, PAH MEN1 4854/4885KMT2A 3048/4885GAA 4379/4885
US-20230242808-A1 PHOTOCHROMIC COMPOUND AND CURABLE COMPOSITION CONTAINING THE PHOTOCHROMIC COMPOUND RB1, CRY2, CDK16 MEN1 2676/4885KMT2A 579/4885GAA 4429/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.