Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.42 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.42 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.42 |
| ▸ | ALB | P02768 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | RARB | P10826 | 1/20 | 0.42 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.42 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.42 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15905964 | 0.84 | TBXAS1 (0.51) | EPHX2PPARGTBXAS1PTGS1PTGS2 | |
| SCHEMBL13594789 | 0.84 | TBXAS1 (0.51) | EPHX2PPARGTBXAS1PTGS1PTGS2 | |
| SCHEMBL13410540 | 0.83 | SLC7A5 (0.57) | PTGS1PTGS2LMNANFKB1HTR2A | |
| SCHEMBL12142605 | 0.83 | SLC7A5 (0.57) | PTGS1PTGS2LMNANFKB1HTR2A | |
| SCHEMBL11237591 | 0.83 | TBXAS1 (0.59) | TBXAS1PTGS1PTGS2LMNACYP2C9 | |
| SCHEMBL14640265 | 0.82 | ALDH1A1 (0.55) | EPHX2PPARGTBXAS1PTGS1PTGS2 | |
| SCHEMBL15905947 | 0.81 | CES2 (0.55) | EPHX2PPARGTBXAS1PTGS1PTGS2 | |
| SCHEMBL23097488 | 0.81 | TAAR1 (0.53) | — | |
| SCHEMBL12142803 | 0.80 | KMT2A (0.55) | EPHX2PPARGTBXAS1PTGS1PTGS2 | |
| SCHEMBL19485698 | 0.80 | KMT2A (0.55) | EPHX2PPARGTBXAS1PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3170821-A1 | COMPOSITIONS CONTAINING, METHODS INVOLVING, AND USES OF NON-NATURAL AMINO ACID LINKED DOLASTATIN DERIVATIVES | Ambrx, Inc. (US) | 2017-05-24 | — | — | EP | disclosed |
| EP-2714685-B1 | COMPOSITIONS CONTAINING, METHODS INVOLVING, AND USES OF NON-NATURAL AMINO ACID LINKED DOLASTATIN DERIVATIVES | AMBRX INC (US) | 2016-10-19 | — | — | EP | disclosed |
| WO-2012166560-A1 | COMPOSITIONS CONTAINING, METHODS INVOLVING, AND USES OF NON-NATURAL AMINO ACID LINKED DOLASTATIN DERIVATIVES | AMBRX, INC. (US) | 2012-12-06 | — | — | WO | disclosed |