Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 4/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | OGG1 | O15527 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16211576 | 0.80 | TSHR (0.52) | TSHRCYP3A4MAPK1TDP1TP53 | |
| SCHEMBL107751 | 0.76 | TSHR (0.62) | TSHRCYP3A4MAPK1TDP1TP53 | |
| SCHEMBL29403188 | 0.76 | TSHR (0.62) | TSHRCYP3A4MAPK1TDP1TP53 | |
| SCHEMBL21995301 | 0.74 | TSHR (0.60) | TSHRCYP3A4MAPK1TDP1TP53 | |
| SCHEMBL16211981 | 0.72 | TSHR (0.58) | TSHRCYP3A4MAPK1TDP1TP53 | |
| SCHEMBL31740316 | 0.72 | TSHR (0.58) | TSHRCYP3A4MAPK1TDP1TP53 | |
| SCHEMBL16401802 | 0.72 | CYP3A4 (0.43) | TSHRCYP3A4MAPK1TDP1TP53 | |
| SCHEMBL10923383 | 0.72 | CYP3A4 (0.47) | TSHRCYP3A4MAPK1TDP1TP53 | |
| SCHEMBL4701959 | 0.70 | CYP19A1 (0.41) | TSHRMAPK1CYP19A1HIF1AMEN1 | |
| SCHEMBL5423724 | 0.69 | TSHR (0.54) | TSHRCYP3A4MAPK1TDP1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10952435-B2 | Pyridine-2-carboxamides as nematocides | SYNGENTA PARTICIPATIONS AG (CH) | 2021-03-23 | — | — | US | disclosed |
| US-10952435-B2 | Pyridine-2-carboxamides as nematocides | SYNGENTA PARTICIPATIONS AG (CH) | 2021-03-23 | — | — | US | disclosed |
| EP-3022181-B1 | PYRIDINE-2-CARBOXAMIDES AS NEMATOCIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2018-03-07 | — | — | EP | disclosed |
| EP-3022181-B1 | PYRIDINE-2-CARBOXAMIDES AS NEMATOCIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2018-03-07 | — | — | EP | disclosed |
| US-20160165887-A1 | PYRIDINE-2-CARBOXAMIDES AS NEMATOCIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2016-06-16 | — | — | US | disclosed |
| US-20160165887-A1 | PYRIDINE-2-CARBOXAMIDES AS NEMATOCIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2016-06-16 | — | — | US | disclosed |
| US-20160165887-A1 | PYRIDINE-2-CARBOXAMIDES AS NEMATOCIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2016-06-16 | — | — | US | disclosed |
| EP-3022181-A1 | PYRIDINE-2-CARBOXAMIDES AS NEMATOCIDES | Syngenta Participations AG (CH) | 2016-05-25 | — | — | EP | disclosed |
| WO-2015007626-A1 | PYRIDINE-2-CARBOXAMIDES AS NEMATOCIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2015-01-22 | — | — | WO | disclosed |
| WO-2015007626-A1 | PYRIDINE-2-CARBOXAMIDES AS NEMATOCIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2015-01-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160165887-A1 | PYRIDINE-2-CARBOXAMIDES AS NEMATOCIDES | TUBA3C, CYCS, ACHE | TSHR 3507/4885CYP3A4 126/4885MAPK1 2587/4885 |
| US-10952435-B2 | Pyridine-2-carboxamides as nematocides | TUBA3C, CYCS, ACHE | TSHR 3507/4885CYP3A4 126/4885MAPK1 2587/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.