Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.35 |
| ▸ | AGTR1 | P30556 | 8/20 | 0.35 |
| ▸ | AGTR2 | P50052 | 6/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2052910 | 0.72 | AGTR1 (0.38) | AGTR1AGTR2 | |
| SCHEMBL9296349 | 0.71 | LTB4R2 (0.33) | LTB4R2AGTR1AGTR2 | |
| SCHEMBL9296356 | 0.71 | LTB4R2 (0.33) | LTB4R2AGTR1AGTR2 | |
| SCHEMBL6953051 | 0.71 | HSD11B1 (0.47) | AGTR1AGTR2 | |
| SCHEMBL9709753 | 0.70 | LTB4R2 (0.42) | LTB4R2AGTR1AGTR2 | |
| SCHEMBL9667305 | 0.70 | AGTR1 (0.46) | LTB4R2AGTR1AGTR2 | |
| SCHEMBL18425480 | 0.69 | LTB4R2 (0.69) | LTB4R2AGTR1 | |
| SCHEMBL594508 | 0.69 | AGTR1 (0.52) | AGTR1AGTR2 | |
| SCHEMBL9709732 | 0.69 | LTB4R2 (0.41) | LTB4R2AGTR1AGTR2 | |
| SCHEMBL3423 | 0.69 | LTB4R2 (0.49) | LTB4R2AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3004138-A2 | ULTRA-PURE AGONISTS OF GUANYLATE CYCLASE C, METHOD OF MAKING AND USING SAME | Synergy Pharmaceuticals Inc. (US) | 2016-04-13 | — | — | EP | disclosed |
| WO-2014197720-A2 | ULTRA-PURE AGONISTS OF GUANYLATE CYCLASE C, METHOD OF MAKING AND USING SAME | SYNERGY PHARMACEUTICALS, INC. (US) | 2014-12-11 | — | — | WO | disclosed |