Ginkolide B

Ginkolide B

SCHEMBL16407904

C[C@@H]1C(=O)O[C@H]2[C@H](O)C34[C@H]5C[C@@H](C(C)(C)C)[C@]36[C@@H](OC(=O)[C@@H]6O)O[C@@]4(C(=O)O5)[C@@]12O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
PTAFR P25105 4/20 1.00
GLRA1 P23415 3/20 1.00
GLRA2 P23416 3/20 1.00
CYP2C9 P11712 1/20 1.00
HSD17B10 Q99714 1/20 1.00
GUSB P08236 1/20 1.00
KMT2A Q03164 2/20 0.67
SMN1; SMN2 Q16637 1/20 0.67
MEN1 O00255 1/20 0.67
KDM4E B2RXH2 1/20 0.66
MAPK1 P28482 1/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ginkolide B SCHEMBL13702797 1.00 PTAFR (1.00) PTAFRGLRA1GLRA2CYP2C9HSD17B10
Ginkolide B SCHEMBL464784 1.00 PTAFR (1.00) PTAFRGLRA1GLRA2CYP2C9HSD17B10
Ginkolide B SCHEMBL29495629 1.00 PTAFR (1.00) PTAFRGLRA1GLRA2CYP2C9HSD17B10
Ginkolide B SCHEMBL464783 1.00 PTAFR (1.00) PTAFRGLRA1GLRA2CYP2C9HSD17B10
Ginkolide B SCHEMBL14029435 1.00 PTAFR (1.00) PTAFRGLRA1GLRA2CYP2C9HSD17B10
Ginkolide B SCHEMBL29410795 1.00 PTAFR (1.00) PTAFRGLRA1GLRA2CYP2C9HSD17B10
Ginkolide B SCHEMBL12714280 1.00 PTAFR (1.00) PTAFRGLRA1GLRA2CYP2C9HSD17B10
Ginkolide B SCHEMBL14279903 1.00 PTAFR (1.00) PTAFRGLRA1GLRA2CYP2C9HSD17B10
SCHEMBL13960075 0.94 PTAFR (0.89) PTAFRGLRA1GLRA2CYP2C9HSD17B10
SCHEMBL13702667 0.94 PTAFR (0.89) PTAFRGLRA1GLRA2CYP2C9HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9084755-B2 Method for extracting and separating ginkgolides CHENGDU BAIYU TECHNOLOGY PHARMACY CO., LTD. (CN) 2015-07-21 US disclosed
US-9084755-B2 Method for extracting and separating ginkgolides CHENGDU BAIYU TECHNOLOGY PHARMACY CO., LTD. (CN) 2015-07-21 US disclosed
US-20150044311-A1 METHOD FOR EXTRACTING AND SEPARATING GINKGOLIDES CHENGDU BAIYU PHARMACEUTICAL CO., LTD. (CN) 2015-02-12 US disclosed
US-20150044311-A1 METHOD FOR EXTRACTING AND SEPARATING GINKGOLIDES CHENGDU BAIYU PHARMACEUTICAL CO., LTD. (CN) 2015-02-12 US disclosed
US-20150025061-A1 GABAA RECEPTOR ANTAGONISTS AFFECTING GANGLION CELL FUNCTION AND VISUAL ACUITY KARAKOSSIAN, Movses 2015-01-22 US disclosed
US-20150025061-A1 GABAA RECEPTOR ANTAGONISTS AFFECTING GANGLION CELL FUNCTION AND VISUAL ACUITY KARAKOSSIAN, Movses 2015-01-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150044311-A1 METHOD FOR EXTRACTING AND SEPARATING GINKGOLIDES COG8, CYP8B1, GTPBP10 PTAFR 4513/4885GLRA1 1288/4885GLRA2 1355/4885
US-20150025061-A1 GABAA RECEPTOR ANTAGONISTS AFFECTING GANGLION CELL FUNCTION AND VISUAL ACUITY GABRA2, GABRB2, GABRB1 PTAFR 1392/4885GLRA1 64/4885GLRA2 48/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.