Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TTR | P02766 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18530848 | 0.86 | LTA4H (0.49) | LTA4HHSP90AA1KMT2AALDH1A1NPSR1 | |
| SCHEMBL13072227 | 0.83 | ALDH1A1 (0.46) | ALDH1A1NPSR1TSHRCRBNKDM4E | |
| SCHEMBL13071791 | 0.82 | ALDH1A1 (0.41) | LTA4HALDH1A1NPSR1TSHRCRBN | |
| SCHEMBL18872085 | 0.82 | CRBN (0.57) | LTA4HKMT2ACRBNNPC1HPGD | |
| SCHEMBL13071951 | 0.80 | KDM4E (0.48) | KMT2AALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL17338672 | 0.78 | ALDH1A1 (0.51) | KMT2AALDH1A1NPSR1TSHRKDM4E | |
| SCHEMBL3255205 | 0.75 | ALDH1A1 (0.49) | LTA4HKMT2AALDH1A1TSHRKDM4E | |
| SCHEMBL13071790 | 0.74 | SPR (0.39) | LTA4HALDH1A1NPSR1TSHRCRBN | |
| SCHEMBL204082 | 0.73 | PIM1 (0.54) | ALDH1A1NPSR1TSHRKDM4ENPC1 | |
| SCHEMBL13072226 | 0.71 | ALDH1A1 (0.41) | LTA4HKMT2AALDH1A1NPSR1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3022194-B1 | INHIBITORS OF LEUKOTRIENE PRODUCTION | BOEHRINGER INGELHEIM INT (DE) | 2017-05-17 | — | — | EP | disclosed |
| US-9573957-B2 | Inhibitors of leukotriene production | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2017-02-21 | — | — | US | disclosed |
| US-9573957-B2 | Inhibitors of leukotriene production | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2017-02-21 | — | — | US | disclosed |
| WO-2015009611-A1 | INHIBITORS OF LEUKOTRIENE PRODUCTION | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-01-22 | — | — | WO | disclosed |