⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22494209 | 0.69 | AKR1B1 (0.35) | — | |
| SCHEMBL329387 | 0.67 | — | — | |
| SCHEMBL1673128 | 0.67 | — | — | |
| SCHEMBL7928126 | 0.67 | — | — | |
| SCHEMBL440583 | 0.66 | — | — | |
| SCHEMBL1258957 | 0.66 | — | — | |
| SCHEMBL21670717 | 0.66 | CA2 (0.39) | — | |
| SCHEMBL4976456 | 0.66 | — | — | |
| Hydrochloric Acid SCHEMBL3710347 | 0.66 | CA2 (0.39) | — | |
| SCHEMBL34468730 | 0.65 | RIPK1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1962 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3984994-B1 | SUBSTITUTED PIPERIDINE COMPOUND AS OREXIN TYPE 2 AGONIST FOR THE TREATMENT OF NARCOLEPSY | TAKEDA PHARMACEUTICALS CO (JP) | 2024-07-03 | — | — | EP | claimed |
| EP-4149933-B1 | NEW TRIAZOLYL DERIVATIVES AS GABA A ALPHA5 PAM | HOFFMANN LA ROCHE (CH) | 2024-06-12 | — | — | EP | claimed |
| US-20240043441-A1 | INHIBITORS OF KRAS G12C | ARAXES PHARMA LLC (US) | 2024-02-08 | — | — | US | claimed |
| US-20230303586-A1 | INHIBITORS OF KRAS G12C | ARAXES PHARMA LLC (US) | 2023-09-28 | — | — | US | claimed |
| US-20230212183-A9 | INHIBITORS OF KRAS G12C | ARAXES PHARMA LLC (US) | 2023-07-06 | — | — | US | claimed |
| US-20230135093-A1 | TRIAZOLYL DERIVATIVES AS GABA A ALPHA5 PAM | HOFFMANN-LA ROCHE INC. (US) | 2023-05-04 | — | — | US | claimed |
| EP-4149933-A1 | NEW TRIAZOLYL DERIVATIVES AS GABA A ALPHA5 PAM | F. Hoffmann-La Roche AG (CH) | 2023-03-22 | — | — | EP | claimed |
| CN-115461337-A | Novel triazolyl derivatives as GABA A alpha 5 PAM | 豪夫迈·罗氏有限公司 | 2022-12-09 | — | — | CN | claimed |
| CN-115403584-A | 2-thio-2, 3-dihydropyrimidine-4-one derivative, pharmaceutical composition, preparation method and application thereof | 长春金赛药业有限责任公司 | 2022-11-29 | — | — | CN | claimed |
| WO-2022240213-A1 | NOVEL BENZOTHIAZOLE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF FOR PREVENTION OR TREATMENT OF LIVER DISEASE | 에이치케이이노엔 주식회사 | 2022-11-17 | — | — | WO | claimed |
| WO-1998005638-A2 | 2- AND 2,5-SUBSTITUTED PHENYLKETOENOLS | BAYER AKTIENGESELLSCHAFT (DE) | 1998-02-12 | — | — | WO | claimed |
| WO-1997036868-A1 | SUBSTITUTED PHENYL KETO ENOLS AS PESTICIDES AND HERBICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 1997-10-09 | — | — | WO | claimed |
| WO-1997001535-A1 | 2,4,5-TRISUBSTITUTED PHENYLKETO-ENOLS FOR USE AS PESTICIDES AND HERBICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 1997-01-16 | — | — | WO | claimed |
| US-5565450-A | PESTICIDES, INSECTICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 1996-10-15 | — | — | US | claimed |
| EP-0439785-B1 | Substituted 2-[6-(pyrimidinyl)-indol-1-yl]-acrylic acid ester | BAYER AG (DE) | 1995-09-27 | — | — | EP | claimed |
| US-5290668-A | Photographic films with waterproof layers on supports for color photography | FUJI PHOTO FILM CO., LTD. (JP) | 1994-03-01 | — | — | US | claimed |
| US-5262416-A | Insecticides or fungicides | BAYER AKTIENGESELLSCHAFT (DE) | 1993-11-16 | — | — | US | claimed |
| US-5244776-A | Method of forming color images | FUJI PHOTO FILM CO., LTD. (JP) | 1993-09-14 | — | — | US | claimed |
| US-5212055-A | Pyrazoloazole coupler, bisphenol, spirobiindane | FUJI PHOTO FILM CO., LTD. (JP) | 1993-05-18 | — | — | US | claimed |
| EP-0439785-A2 | Substituted 2-[6-(pyrimidinyl)-indol-1-yl]-acrylic acid ester | BAYER AG (DE) | 1991-08-07 | — | — | EP | claimed |