Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | CYP17A1 | P05093 | 5/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.35 |
| ▸ | ALPL | P05186 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | B3GNT2 | Q9NY97 | 2/20 | 0.35 |
| ▸ | PPARG | P37231 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1285045 | 0.85 | PTPN1 (0.42) | NR1H4CYP17A1CYP3A4PTPN1 | |
| SCHEMBL1643125 | 0.84 | CYP17A1 (0.40) | NR1H4CYP17A1CYP3A4PDE2ACACNA1I | |
| SCHEMBL1644338 | 0.82 | NR1H4 (0.48) | NR1H4PDE2AALDH1A1ROCK2ROCK1 | |
| SCHEMBL1644460 | 0.78 | NR1H4 (0.38) | NR1H4CYP17A1CYP3A4PDE2AGAA | |
| SCHEMBL1644853 | 0.75 | PDE2A (0.43) | CYP17A1CYP3A4PDE2AB3GNT2 | |
| SCHEMBL14378392 | 0.74 | CYP17A1 (0.41) | NR1H4CYP17A1CYP3A4PDE2ACACNA1I | |
| SCHEMBL1645545 | 0.73 | PDE2A (0.42) | NR1H4CYP3A4PDE2AALDH1A1PPARG | |
| SCHEMBL21467201 | 0.73 | CYP17A1 (0.57) | NR1H4CYP17A1CYP3A4ALDH1A1PTPN1 | |
| SCHEMBL2903698 | 0.72 | NR1H4 (0.56) | NR1H4CYP17A1CYP3A4PDE2AALDH1A1 | |
| SCHEMBL1643047 | 0.72 | NR1H4 (0.41) | NR1H4PDE2AGAAHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120088746-A1 | AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME | PFIZER INC. (US) | 2012-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120088746-A1 | AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME | TRPV1, TRPA1, TRPV2 | NR1H4 732/4885CYP17A1 4396/4885CYP3A4 2021/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.