Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 1/20 | 0.54 |
| ▸ | DHODH | Q02127 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 6/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 5/20 | 0.45 |
| ▸ | GSK3B | P49841 | 3/20 | 0.45 |
| ▸ | GSK3A | P49840 | 2/20 | 0.45 |
| ▸ | SRC | P12931 | 2/20 | 0.45 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.45 |
| ▸ | PLK4 | O00444 | 1/20 | 0.44 |
| ▸ | PAK4 | O96013 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 4/20 | 0.44 |
| ▸ | JAK3 | P52333 | 4/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | JAK1 | P23458 | 2/20 | 0.43 |
| ▸ | TYK2 | P29597 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1704457 | 0.78 | ITK (0.55) | ITKAURKAAURKBSRC | |
| SCHEMBL3532347 | 0.76 | ITK (0.50) | ITKDHODHAURKAAURKBNTRK1 | |
| SCHEMBL3529643 | 0.76 | ITK (0.50) | ITKDHODHAURKAAURKBGSK3B | |
| SCHEMBL24742377 | 0.76 | ITK (0.50) | ITKDHODHAURKAAURKBNTRK1 | |
| SCHEMBL13072363 | 0.76 | ITK (0.50) | ITKDHODHAURKAAURKBNTRK1 | |
| SCHEMBL902289 | 0.74 | ITK (0.54) | ITKDHODHAURKAAURKBGSK3B | |
| SCHEMBL30377282 | 0.73 | MEN1 (0.48) | ITKDHODHAURKAAURKBNTRK1 | |
| SCHEMBL30230471 | 0.73 | ITK (0.65) | ITKDHODHAURKAAURKBGSK3B | |
| SCHEMBL18154707 | 0.73 | ITK (0.65) | ITKDHODHAURKAAURKBGSK3B | |
| SCHEMBL18297117 | 0.73 | JAK2 (0.46) | ITKDHODHAURKAAURKBNTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10092556-B2 | Piperidine compound or salt thereof | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2018-10-09 | — | — | US | disclosed |
| US-20160228427-A1 | NOVEL PIPERIDINE COMPOUND OR SALT THEREOF | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2016-08-11 | — | — | US | disclosed |
| US-9346787-B2 | Piperidine compound or salt thereof | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2016-05-24 | — | — | US | disclosed |
| US-20150045342-A1 | NOVEL PIPERIDINE COMPOUND OR SALT THEREOF | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2015-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10092556-B2 | Piperidine compound or salt thereof | TUBB6, KIF5A, TUBB3 | ITK 3693/4885DHODH 2860/4885AURKA 7/4885 |
| US-20150045342-A1 | NOVEL PIPERIDINE COMPOUND OR SALT THEREOF | KIF5A, TUBB6, AURKC | ITK 3880/4885DHODH 2944/4885AURKA 5/4885 |
| US-20160228427-A1 | NOVEL PIPERIDINE COMPOUND OR SALT THEREOF | KIF5A, TUBB6, AURKC | ITK 3880/4885DHODH 2944/4885AURKA 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.