Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 1/20 | 0.54 |
| ▸ | AURKA | O14965 | 8/20 | 0.54 |
| ▸ | GSK3B | P49841 | 3/20 | 0.54 |
| ▸ | SRC | P12931 | 3/20 | 0.54 |
| ▸ | GSK3A | P49840 | 2/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 8/20 | 0.47 |
| ▸ | KARS1 | Q15046 | 5/20 | 0.46 |
| ▸ | EGFR | P00533 | 2/20 | 0.44 |
| ▸ | IGF1R | P08069 | 2/20 | 0.44 |
| ▸ | FLT4 | P35916 | 2/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | INSR | P06213 | 1/20 | 0.44 |
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1704457 | 0.83 | ITK (0.55) | ITKAURKASRCAURKBKARS1 | |
| SCHEMBL902672 | 0.77 | KARS1 (0.74) | GSK3BGSK3AKARS1IGF1RKDR | |
| SCHEMBL13963122 | 0.76 | GSK3B (0.46) | ITKAURKAGSK3BSRCGSK3A | |
| SCHEMBL802341 | 0.76 | GSK3B (0.46) | ITKAURKAGSK3BSRCGSK3A | |
| SCHEMBL4171445 | 0.76 | GSK3B (0.57) | ITKAURKAGSK3BSRCGSK3A | |
| SCHEMBL1704696 | 0.76 | KARS1 (0.67) | ITKAURKAGSK3BSRCGSK3A | |
| SCHEMBL1704417 | 0.76 | KARS1 (0.76) | ITKAURKAAURKBKARS1 | |
| SCHEMBL802363 | 0.75 | AURKA (0.62) | ITKAURKAGSK3BSRCGSK3A | |
| SCHEMBL3966931 | 0.75 | AURKA (0.58) | ITKAURKAGSK3BSRCGSK3A | |
| SCHEMBL802122 | 0.75 | AURKA (0.49) | ITKAURKAGSK3BSRCGSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |