Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 1/20 | 0.55 |
| ▸ | SYK | P43405 | 2/20 | 0.52 |
| ▸ | KARS1 | Q15046 | 10/20 | 0.47 |
| ▸ | AURKA | O14965 | 4/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.45 |
| ▸ | KDR | P35968 | 3/20 | 0.45 |
| ▸ | EGFR | P00533 | 2/20 | 0.45 |
| ▸ | FLT4 | P35916 | 2/20 | 0.45 |
| ▸ | IGF1R | P08069 | 2/20 | 0.45 |
| ▸ | INSR | P06213 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL902289 | 0.83 | ITK (0.54) | ITKKARS1AURKAAURKBKDR | |
| SCHEMBL902707 | 0.82 | SYK (0.76) | SYKKARS1KDRIGF1R | |
| SCHEMBL16444835 | 0.78 | ITK (0.54) | ITKAURKAAURKBSRC | |
| SCHEMBL1704417 | 0.78 | KARS1 (0.76) | ITKKARS1AURKAAURKB | |
| SCHEMBL902695 | 0.77 | KARS1 (0.60) | SYKKARS1MAPT | |
| SCHEMBL1705645 | 0.74 | KARS1 (0.56) | ITKSYKKARS1AURKAAURKB | |
| SCHEMBL1704696 | 0.73 | KARS1 (0.67) | ITKKARS1AURKAAURKBKDR | |
| SCHEMBL18154707 | 0.72 | ITK (0.65) | ITKAURKAAURKBKDREGFR | |
| SCHEMBL30230471 | 0.72 | ITK (0.65) | ITKAURKAAURKBKDREGFR | |
| SCHEMBL802275 | 0.71 | ITK (1.00) | ITKAURKAAURKBKDREGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |