SCHEMBL16446124

SCHEMBL16446124

N#CC(CC(F)F)N=C(c1ccccc1)c1ccccc1

nearest known ligand 0.36

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.36
SMN1; SMN2 Q16637 3/20 0.35
ALDH1A1 P00352 3/20 0.35
HPGD P15428 2/20 0.35
CYP1A2 P05177 1/20 0.35
CYP3A4 P08684 1/20 0.35
CYP2D6 P10635 1/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2C19 P33261 1/20 0.35
POLB P06746 1/20 0.33
AAK1 Q2M2I8 1/20 0.33
LMNA P02545 1/20 0.33
ALPG P10696 1/20 0.33
RAB9A P51151 1/20 0.33
CYP19A1 P11511 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28169241 0.98 TSHR (0.35) TSHRSMN1; SMN2ALDH1A1HPGDCYP1A2
SCHEMBL16446063 0.80 AAK1 (0.39) TSHRSMN1; SMN2ALDH1A1HPGDCYP1A2
SCHEMBL26696020 0.79 AAK1 (0.41) TSHRSMN1; SMN2ALDH1A1HPGDCYP1A2
SCHEMBL16075175 0.78 MDM2 (0.41) SMN1; SMN2ALDH1A1HPGDCYP1A2CYP3A4
SCHEMBL16446183 0.78 AAK1 (0.35) TSHRSMN1; SMN2ALDH1A1HPGDCYP1A2
SCHEMBL11117263 0.77 ALDH1A1 (0.38) TSHRSMN1; SMN2ALDH1A1HPGDCYP1A2
SCHEMBL1668920 0.75 LMNA (0.41) SMN1; SMN2ALDH1A1HPGDLMNAALPG
SCHEMBL11129929 0.74 NR4A2 (0.41) TSHRSMN1; SMN2ALDH1A1HPGDCYP1A2
SCHEMBL16064523 0.74 LMNA (0.32) SMN1; SMN2ALDH1A1HPGDLMNAALPG
SCHEMBL2617314 0.73 CTSC (0.40) CYP1A2CYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250376461-A1 INDAZOLE DERIVATIVES FOR TREATING TRPM3-MEDIATED DISORDERS UNIV LEUVEN KATH (BE) 2025-12-11 US disclosed
CN-119968362-A Indazole derivatives for the treatment of TRPM3 mediated disorders 勒芬天主教大学 2025-05-09 CN disclosed
EP-4499624-A2 INDAZOLE DERIVATIVES FOR TREATING TRPM3-MEDIATED DISORDERS Katholieke Universiteit Leuven KU Leuven Research & Development (BE) 2025-02-05 EP disclosed
WO-2023230540-A2 INDAZOLE DERIVATIVES FOR TREATING TRPM3-MEDIATED DISORDERS KATHOLIEKE UNIVERSITEIT LEUVEN (BE) 2023-11-30 WO disclosed
CN-107074772-A Substituted formamide of quinoline 4 and application thereof 拜耳医药股份有限公司 2017-08-18 CN disclosed
US-20170233345-A1 SUBSTITUTED QUINOLINE-4-CARBOXAMIDES AND USE THEREOF BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2017-08-17 US disclosed
US-20170233413-A1 SUBSTITUTED ANNULATED PYRIMIDINES AND USE THEREOF BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2017-08-17 US disclosed
US-20170233413-A1 SUBSTITUTED ANNULATED PYRIMIDINES AND USE THEREOF BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2017-08-17 US disclosed
US-20170233345-A1 SUBSTITUTED QUINOLINE-4-CARBOXAMIDES AND USE THEREOF BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2017-08-17 US disclosed
US-20170233345-A1 SUBSTITUTED QUINOLINE-4-CARBOXAMIDES AND USE THEREOF BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2017-08-17 US disclosed
WO-2016023885-A1 SUBSTITUTED QUINOLINE-4-CARBOXAMIDES AND USE THEREOF BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2016-02-18 WO disclosed
WO-2016023885-A1 SUBSTITUTED QUINOLINE-4-CARBOXAMIDES AND USE THEREOF BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2016-02-18 WO disclosed
WO-2015165930-A1 ENANTIOMERS OF THE N-(2-AMINO-5-FLUORO-2-METHYLPENTYL)-8-[(2,6-DIFLUOROBENZYL)OXY]-2-METHYLIMIDAZO[1,2-A]PYRIDINE-3-CARBOXAMIDE, AS WELL AS OF THE DI- AND TRIFLUORO DERIVATIVES FOR THE TREATMENT OF CARDIOVASCULAR DISEASES BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2015-11-05 WO disclosed
WO-2015165930-A1 ENANTIOMERS OF THE N-(2-AMINO-5-FLUORO-2-METHYLPENTYL)-8-[(2,6-DIFLUOROBENZYL)OXY]-2-METHYLIMIDAZO[1,2-A]PYRIDINE-3-CARBOXAMIDE, AS WELL AS OF THE DI- AND TRIFLUORO DERIVATIVES FOR THE TREATMENT OF CARDIOVASCULAR DISEASES BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2015-11-05 WO disclosed
WO-2015165970-A1 6-CHLORINE-SUBSTITUTED IMIDAZO[1,2-A]PYRIDINE CARBOXAMIDES AND THE USE THEREOF AS SOLUBLE GUANYLATE CYCLASE STIMULATORS BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2015-11-05 WO disclosed
WO-2015165970-A1 6-CHLORINE-SUBSTITUTED IMIDAZO[1,2-A]PYRIDINE CARBOXAMIDES AND THE USE THEREOF AS SOLUBLE GUANYLATE CYCLASE STIMULATORS BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2015-11-05 WO disclosed
WO-2015018808-A1 SUBSTITUTED IMIDAZO[1,2-A]PYRAZINECARBOXAMIDES AND USE THEREOF BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2015-02-12 WO disclosed
WO-2015018808-A1 SUBSTITUTED IMIDAZO[1,2-A]PYRAZINECARBOXAMIDES AND USE THEREOF BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2015-02-12 WO disclosed
WO-2015018814-A1 SUBSTITUTED PYRAZOLO[1,5-A]-PYRIDINE-3-CARBOXAMIDES AND USE THEREOF BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2015-02-12 WO disclosed
WO-2015018814-A1 SUBSTITUTED PYRAZOLO[1,5-A]-PYRIDINE-3-CARBOXAMIDES AND USE THEREOF BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2015-02-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170233345-A1 SUBSTITUTED QUINOLINE-4-CARBOXAMIDES AND USE THEREOF NQO2, SIRT5, BRD4 TSHR 3720/4885SMN1; SMN2 3031/4885ALDH1A1 1771/4885
US-20170233413-A1 SUBSTITUTED ANNULATED PYRIMIDINES AND USE THEREOF TYMP, DPYD, TYMS TSHR 4577/4885SMN1; SMN2 1171/4885ALDH1A1 660/4885
US-20250376461-A1 INDAZOLE DERIVATIVES FOR TREATING TRPM3-MEDIATED DISORDERS TRPV3, TRPM2, TRPV1 TSHR 3733/4885SMN1; SMN2 3214/4885ALDH1A1 1658/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.