SCHEMBL16449102

SCHEMBL16449102

CC(C)(C)c1cc(CNC(=O)CNC(=O)CNC(=O)CN)cc(C(C)(C)C)c1

nearest known ligand 0.44

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.44
KMT2A Q03164 1/20 0.44
CA1 P00915 2/20 0.42
CA2 P00918 2/20 0.42
CA12 O43570 1/20 0.42
CA7 P43166 1/20 0.42
AOC3 Q16853 2/20 0.42
ALDH1A1 P00352 1/20 0.39
EPHX2 P34913 2/20 0.38
NR1H4 Q96RI1 1/20 0.38
TACR1 P25103 1/20 0.38
TERT O14746 1/20 0.38
PRSS1 P07477 1/20 0.38
TPSAB1 Q15661 1/20 0.38
TPSD1 Q9BZJ3 1/20 0.38
TPSG1 Q9NRR2 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16448820 0.94 AOC3 (0.46) CA1CA2CA12CA7AOC3
SCHEMBL16261160 0.88 MEN1 (0.47) MEN1KMT2ACA1CA2CA12
SCHEMBL14672763 0.79 TACR1 (0.42) EPHX2NR1H4TACR1
SCHEMBL16017545 0.78 ALDH1A1 (0.43) MEN1KMT2ACA1CA2AOC3
SCHEMBL18232499 0.78 EPHX2 (0.60) MEN1KMT2ACA1CA2CA12
SCHEMBL15844016 0.78 TACR1 (0.58) CA1CA2AOC3ALDH1A1TACR1
SCHEMBL16259478 0.77 EPHX2 (0.47) MEN1KMT2ACA1CA2EPHX2
SCHEMBL2341110 0.75 LMNA (0.47) MEN1KMT2AEPHX2NR1H4TACR1
SCHEMBL16261291 0.72 HDAC1 (0.49) MEN1KMT2AALDH1A1EPHX2TPSAB1
SCHEMBL26580966 0.72 AOC3 (0.64) MEN1KMT2ACA1CA2AOC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9085548-B2 Pseudorotaxanes, rotaxanes and catenanes formed by metal ions templating NATIONAL TAIWAN UNIVERSITY (TW) 2015-07-21 US disclosed
US-20150051393-A1 PSEUDOROTAXANES, ROTAXANES AND CATENANES FORMED BY METAL IONS TEMPLATING NATIONAL TAIWAN UNIVERSITY (TW) 2015-02-19 US disclosed
US-8952167-B2 Pseudorotaxanes, rotaxanes and catenanes formed by metal ions templating NATIONAL TAIWAN UNIVERSITY (TW) 2015-02-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150051393-A1 PSEUDOROTAXANES, ROTAXANES AND CATENANES FORMED BY METAL IONS TEMPLATING PCNA, TIMCC, SGTA MEN1 2657/4885KMT2A 2789/4885CA1 6/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.