Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | BCL3 | P20749 | 1/20 | 0.43 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 3/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.42 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.42 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.42 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.42 |
| ▸ | TGM2 | P21980 | 4/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16455184 | 0.89 | SLC6A2 (0.45) | KMT2ABCL3KDM1ATGM2CNR1 | |
| SCHEMBL16455182 | 0.87 | KDM1A (0.53) | KMT2AKDM1ATGM2MEN1MAPT | |
| SCHEMBL16455199 | 0.80 | KMT2A (0.49) | KMT2ATGM2NPC1P2RY12MAPT | |
| SCHEMBL18848468 | 0.78 | CTSB (0.55) | KMT2AKDM1ANPC1MEN1P2RY12 | |
| SCHEMBL18059540 | 0.77 | KDM1A (0.44) | KDM1ATGM2 | |
| SCHEMBL18848623 | 0.77 | KDM1A (0.44) | KDM1ATGM2 | |
| SCHEMBL16455163 | 0.76 | KDM1A (0.53) | KDM1ATGM2 | |
| SCHEMBL16455166 | 0.76 | KDM1A (0.59) | KDM1ATGM2 | |
| SCHEMBL16447253 | 0.74 | KDM1A (0.53) | KDM1A | |
| SCHEMBL18848746 | 0.74 | KDM1A (0.58) | KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017079753-A1 | LYSINE-SPECIFIC HISTONE DEMETHYLASE AS A NOVEL THERAPEUTIC TARGET IN MYELOPROLIFERATIVE NEOPLASMS | IMAGO BIOSCIENCES, INC. (US) | 2017-05-11 | — | — | WO | disclosed |