Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TRPV3 | Q8NET8 | 2/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HPGDS | O60760 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16457344 | 0.89 | PRKCB (0.43) | THRBMAPTKDM4ETRPV3DPP4 | |
| SCHEMBL9927822 | 0.88 | KDM4E (0.44) | THRBMAPTKDM4ETRPV3CNR1 | |
| SCHEMBL16457414 | 0.88 | HDAC4 (0.40) | THRBMAPTKDM4ETRPV3DPP4 | |
| SCHEMBL16457229 | 0.86 | GPR119 (0.40) | THRBMAPTKDM4EGPR119 | |
| SCHEMBL16456980 | 0.86 | THRB (0.42) | THRBMAPTKDM4ETRPV3CNR1 | |
| SCHEMBL16457196 | 0.86 | KDM4E (0.42) | THRBMAPTKDM4ETRPV3CNR1 | |
| SCHEMBL16457324 | 0.85 | GPR119 (0.45) | THRBMAPTKDM4ETRPV3CNR1 | |
| SCHEMBL16457697 | 0.84 | KDM4E (0.44) | THRBMAPTKDM4ETRPV3CNR1 | |
| SCHEMBL1662349 | 0.84 | THRB (0.36) | THRBMAPTKDM4ETRPV3DPP4 | |
| SCHEMBL16457034 | 0.84 | TRPV3 (0.45) | THRBMAPTKDM4ETRPV3CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2491032-B1 | AKT INHIBITORS | LILLY CO ELI (US) | 2014-04-16 | — | — | EP | disclosed |