Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | HTT | P42858 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.46 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 5/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | USP2 | O75604 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CTSL | P07711 | 2/20 | 0.44 |
| ▸ | CTSS | P25774 | 2/20 | 0.44 |
| ▸ | CTSK | P43235 | 2/20 | 0.44 |
| ▸ | CTSB | P07858 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16459016 | 0.87 | NPY5R (0.50) | ALDH1A1HTTHPGDNPY5RPTGES2 | |
| SCHEMBL15195223 | 0.84 | PSMB5 (0.45) | ALDH1A1HTTHPGDNPY5RPTGES2 | |
| SCHEMBL12225904 | 0.84 | PSMB5 (0.45) | ALDH1A1HTTHPGDNPY5RPTGES2 | |
| SCHEMBL3153318 | 0.81 | PSMB5 (0.48) | ALDH1A1HTTHPGDNPY5RPTGES2 | |
| SCHEMBL19687309 | 0.80 | ALDH1A1 (0.42) | ALDH1A1HTTHPGDNPY5RPTGES2 | |
| SCHEMBL16459579 | 0.77 | CTSL (0.43) | NPY5RPOLBCTSLCTSSCTSK | |
| SCHEMBL16460255 | 0.73 | MMP2 (0.50) | ALDH1A1NPY5RMAPTCTSLCTSS | |
| SCHEMBL16458894 | 0.73 | MMP2 (0.47) | ALDH1A1NPY5RMAPTCTSLCTSS | |
| SCHEMBL16458533 | 0.73 | MMP2 (0.51) | ALDH1A1NPY5RMAPTPOLBCTSL | |
| SCHEMBL16458946 | 0.72 | NPY5R (0.43) | ALDH1A1NPY5RMAPTPOLBMMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140011998-A1 | DERIVATIVES OF 1-AMINO-2-CYCLOPROPYLETHYLBORONIC ACID | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2014-01-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140011998-A1 | DERIVATIVES OF 1-AMINO-2-CYCLOPROPYLETHYLBORONIC ACID | PSMB6, PSMB5, PSMB1 | ALDH1A1 2471/4885HTT 258/4885HPGD 3443/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.