Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | PSMB5 | P28074 | 3/20 | 0.41 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | CTSL | P07711 | 2/20 | 0.40 |
| ▸ | CTSS | P25774 | 2/20 | 0.40 |
| ▸ | CTSK | P43235 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3153318 | 0.93 | PSMB5 (0.48) | ALDH1A1HTTHPGDGAALMNA | |
| SCHEMBL15195223 | 0.89 | PSMB5 (0.45) | ALDH1A1HTTHPGDGAALMNA | |
| SCHEMBL12225904 | 0.89 | PSMB5 (0.45) | ALDH1A1HTTHPGDGAALMNA | |
| SCHEMBL16459016 | 0.83 | NPY5R (0.50) | ALDH1A1HTTHPGDGAALMNA | |
| SCHEMBL19387801 | 0.80 | PSMB5 (0.45) | PSMB5CTSLCTSSCTSKPSMB11 | |
| SCHEMBL16458831 | 0.80 | ALDH1A1 (0.47) | ALDH1A1HTTHPGDGAALMNA | |
| SCHEMBL19387844 | 0.75 | F2 (0.44) | PSMB5MMP1MMP2MMP9MMP8 | |
| SCHEMBL19387845 | 0.74 | PSMB5 (0.70) | HTTPSMB5MMP1MMP2MMP9 | |
| SCHEMBL19686572 | 0.74 | PSMB5 (0.49) | PSMB5PSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL3148972 | 0.74 | NPY5R (0.56) | PSMB5NPY5RPSMB11PSMA7PSMB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10035811-B2 | Derivatives of 1-amino-2-cyclobutylethylboronic acid | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2018-07-31 | — | — | US | disclosed |
| US-20170349611-A1 | DERIVATIVES OF 1-AMINO-2-CYCLOBUTYLETHYLBORONIC ACID | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2017-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10035811-B2 | Derivatives of 1-amino-2-cyclobutylethylboronic acid | PSMB6, PSMB5, PSMB1 | ALDH1A1 4010/4885HTT 172/4885HPGD 4256/4885 |
| US-20170349611-A1 | DERIVATIVES OF 1-AMINO-2-CYCLOBUTYLETHYLBORONIC ACID | PSMB6, PSMB5, PSMB1 | ALDH1A1 4010/4885HTT 172/4885HPGD 4256/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.