Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | ESR1 | P03372 | 4/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.36 |
| ▸ | AOC3 | Q16853 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL322574 | 0.82 | TDP1 (0.45) | TDP1CYP3A4ESR1ESR2ALDH1A1 | |
| SCHEMBL2574194 | 0.78 | MEN1 (0.42) | TDP1CYP3A4ESR1ESR2ALDH1A1 | |
| SCHEMBL14617914 | 0.78 | CYP3A4 (0.41) | TDP1CYP3A4ESR1ESR2ALDH1A1 | |
| SCHEMBL17190347 | 0.78 | TDP1 (0.41) | TDP1CYP3A4ESR1ESR2ALDH1A1 | |
| SCHEMBL4797776 | 0.77 | TDP1 (0.45) | TDP1CYP3A4ESR1ESR2ALDH1A1 | |
| SCHEMBL14271678 | 0.76 | TAAR1 (0.39) | TDP1CYP3A4ALDH1A1TSHRAOC3 | |
| SCHEMBL28635021 | 0.75 | TDP1 (0.50) | TDP1CYP3A4ESR1ESR2ALDH1A1 | |
| SCHEMBL14483875 | 0.74 | TDP1 (0.43) | TDP1CYP3A4ESR1ESR2ALDH1A1 | |
| SCHEMBL10711587 | 0.74 | ACHE (0.44) | TDP1ALDH1A1TSHRMEN1HTT | |
| SCHEMBL16841448 | 0.74 | TDP1 (0.38) | TDP1CYP3A4ESR1ESR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 61 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7999100-B2 | Method for chiral inversion of (S)-(+)-and (R)-(−)-10,11-dihydro-10-hydroxy-5H-dibenz/b,f/azepine-5-carboxamide and optically enriched mixtures thereof | Bial-Portela CA & S.A. (PT) | 2011-08-16 | — | — | US | claimed |
| CN-100582095-C | Chiral inversion methods for (S)-(+)-and (R)-(-)-10, 11-dihydro-10-hydroxy-5H-dibenzo/b, f/aza-5-carboxamides and optically enriched mixtures thereof | PORTELA & CA SA | 2010-01-20 | — | — | CN | claimed |
| EP-1789395-B8 | METHOD FOR CHIRAL INVERSION OF (S)-(+)- AND (R)-(-)-10,11-DIHYDRO-10-HYDROXY-5H-DIBENZ/B,F/AZEPINE-5-CARBOXAMIDE AND OPTICALLY ENRICHED MIXTURES THEREOF | BIAL PORTELA & CA SA (PT) | 2009-08-12 | — | — | EP | claimed |
| EP-1789395-B1 | METHOD FOR CHIRAL INVERSION OF (S)-(+)- AND (R)-(-)-10,11-DIHYDRO-10-HYDROXY-5H-DIBENZ/B,F/AZEPINE-5-CARBOXAMIDE AND OPTICALLY ENRICHED MIXTURES THEREOF | BIAL PORTELA & CA SA (PT) | 2009-01-14 | — | — | EP | claimed |
| US-20080293934-A1 | Method for Chiral Inversion of (S)-(+)-and (R)-(-)-10,11-Dihydro-10-Hydroxy-5H-Dibenz/B,F/Azepine-5-Carboxamide and Optically Enriched Mixtures Thereof | BIAL - PORTELA & CA, S.A. (PT) | 2008-11-27 | — | — | US | claimed |
| CN-101023061-A | Method for chiral inversion of (S)-(+)- and (R)-(-)-10,11-dihydro-10-hydroxy-5h-dibenz/b,f/azepine-5-carboxamide and optically enriched mixtures thereof | PORTELA & CA SA (PT) | 2007-08-22 | — | — | CN | claimed |
| EP-1789395-A1 | METHOD FOR CHIRAL INVERSION OF (S)-(+)- AND (R)-(-)-10,11-DIHYDRO-10-HYDROXY-5H-DIBENZ/B,F/AZEPINE-5-CARBOXAMIDE AND OPTICALLY ENRICHED MIXTURES THEREOF | Portela & CA SA (PT) | 2007-05-30 | — | — | EP | claimed |
| WO-2006005951-A1 | METHOD FOR CHIRAL INVERSION OF (S)-(+)- AND (R)-(-)-10,11-DIHYDRO-10-HYDROXY-5H-DIBENZ/B,F/AZEPINE-5-CARBOXAMIDE AND OPTICALLY ENRICHED MIXTURES THEREOF | PORTELA & C.A. S.A. (PT) | 2006-01-19 | — | — | WO | claimed |
| CN-122006631-A | Device for preparing hydrogen fluoride by molecular recognition complexation method and application thereof | 浙江大学衢州研究院 | 2026-05-12 | — | — | CN | disclosed |
| EP-3013832-B1 | PYRAZOLE COMPOUNDS AS MODULATORS OF FSHR AND USES THEREOF | MERCK PATENT GMBH (DE) | 2020-11-04 | — | — | EP | disclosed |
| EP-2953457-B1 | ERK INHIBITORS AND USES THEREOF | CELGENE CAR LLC (BM) | 2020-04-08 | — | — | EP | disclosed |
| EP-2964628-B1 | NEW DIHYDROQUINOLINE-2-ONE DERIVATIVES AS ALDOSTERONE SYNTHASE (CYP11B2 OR CYP11B1) INHIBITORS | HOFFMANN LA ROCHE (CH) | 2019-09-11 | — | — | EP | disclosed |
| CN-105102445-B | Novel dihydroquinolin-2-one derivatives as aldosterone synthase (CYP11B2 or CYP11B1) inhibitors | 豪夫迈·罗氏有限公司 | 2018-10-23 | — | — | CN | disclosed |
| US-9980964-B2 | ERK inhibitors and uses thereof | CELGENE CAR LLC (BM) | 2018-05-29 | — | — | US | disclosed |
| EP-0161979-A1 | Process for dimerizung a conjugated diene | Société Chimique des Charbonnages S.A. (FR) | 1985-11-21 | — | — | EP | disclosed |
| EP-0017422-B1 | THERMOPLASTIC POLYAMIDEIMIDE COPOLYMERS AND METHOD OF PREPARATION | TORAY INDUSTRIES, INC. (JP) | 1983-11-30 | — | — | EP | disclosed |
| US-4299945-A | HEAT POLYMERIZATION OF AN AROMATIC DIAMINO COMPOUND AND AN AROMATIC TRIBASIC CARBOXYLIC ACID | TORAY INDUSTRIES, INC. (JP) | 1981-11-10 | — | — | US | disclosed |
| EP-0017422-A1 | Thermoplastic polyamideimide copolymers and method of preparation | TORAY INDUSTRIES, INC. (JP) | 1980-10-15 | — | — | EP | disclosed |
| US-4145559-A | Esters of 4-substituted 2-methyleneglutaric acids and method for preparing same | ROHM AND HAAS COMPANY (US) | 1979-03-20 | — | — | US | disclosed |
| US-4028429-A | ORGANONICKEL-ALUMINUM-AMINEPHOSPHINE COMPLEX | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1977-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293934-A1 | Method for Chiral Inversion of (S)-(+)-and (R)-(-)-10,11-Dihydro-10-Hydroxy-5H-Dibenz/B,F/Azepine-5-Carboxamide and Optically Enriched Mixtures Thereof | HTR2B, HTR5A, FHIT | TDP1 4327/4885CYP3A4 345/4885ESR1 3092/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.