Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.61 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | BCHE | P06276 | 1/20 | 0.52 |
| ▸ | ACHE | P22303 | 1/20 | 0.52 |
| ▸ | CCR8 | P51685 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3708052 | 0.82 | MCHR1 (0.70) | HRH3MCHR1KDM4ESIGMAR1ALDH1A1 | |
| SCHEMBL341816 | 0.82 | ACHE (0.51) | MCHR1KDM4EALOX15TDP1SIGMAR1 | |
| SCHEMBL6310838 | 0.79 | SIGMAR1 (0.58) | HRH3MCHR1SIGMAR1ALDH1A1ACHE | |
| SCHEMBL5540732 | 0.78 | MCHR1 (0.50) | HRH3MCHR1TSHRALDH1A1ACHE | |
| SCHEMBL9871141 | 0.73 | MCHR1 (0.76) | MCHR1KDM4ESIGMAR1ALDH1A1 | |
| SCHEMBL14543174 | 0.73 | SIGMAR1 (0.58) | MCHR1KDM4EALOX15TDP1SIGMAR1 | |
| SCHEMBL11098754 | 0.72 | GAA (0.59) | KDM4ETDP1TSHRALDH1A1BCHE | |
| SCHEMBL10107601 | 0.71 | SLC6A12 (0.83) | MCHR1SIGMAR1ACHE | |
| SCHEMBL6500308 | 0.71 | SIGMAR1 (0.81) | MCHR1SIGMAR1CCR8 | |
| SCHEMBL1789399 | 0.71 | MCHR1 (0.76) | MCHR1SIGMAR1TSHRACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4664564-B2 | — | — | 2011-04-06 | — | — | JP | claimed |
| JP-2003531829-A | — | — | 2003-10-28 | — | — | JP | claimed |
| EP-1263729-A1 | AZACYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF SEROTONIN RELATED DISEASES | Acadia Pharmaceuticals Inc. (US) | 2002-12-11 | — | — | EP | claimed |
| WO-2001066521-A1 | AZACYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF SEROTONIN RELATED DISEASES | ACADIA PHARMACEUTICALS, INC. (US) | 2001-09-13 | — | — | WO | claimed |