Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 5/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | PTGES | O14684 | 2/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | BACE1 | P56817 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3708052 | 0.83 | MCHR1 (0.70) | MCHR1HRH3ACHEBACE1ALDH1A1 | |
| SCHEMBL6310838 | 0.81 | SIGMAR1 (0.58) | MCHR1HRH3ACHEBACE1ALDH1A1 | |
| SCHEMBL1646804 | 0.78 | HRH3 (0.61) | MCHR1HRH3ACHEALDH1A1TSHR | |
| SCHEMBL341179 | 0.78 | CCR5 (0.55) | HRH3HTR2ACHRM2CHRM1 | |
| SCHEMBL29221786 | 0.77 | PTGES (0.72) | PTGESALDH1A1LMNATSHRNPSR1 | |
| SCHEMBL29221806 | 0.73 | TSHR (0.76) | PTGESALDH1A1LMNATSHRNPSR1 | |
| SCHEMBL29221791 | 0.73 | TSHR (0.76) | PTGESALDH1A1LMNATSHRNPSR1 | |
| SCHEMBL18143018 | 0.72 | OPRM1 (0.49) | HTR2ACHRM2CHRM3 | |
| SCHEMBL5073854 | 0.70 | L3MBTL1 (0.48) | MCHR1ALDH1A1TSHRL3MBTL1DRD4 | |
| SCHEMBL19086863 | 0.69 | SIGMAR1 (0.68) | POLBDRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1787984-B1 | AZACYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF SEROTONIN RELATED DISEASES | ACADIA PHARM INC (US) | 2016-10-19 | — | — | EP | disclosed |
| EP-1787984-A2 | AZACYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF SEROTONIN RELATED DISEASES | Arcadia Pharmaceuticals Inc. (US) | 2007-05-23 | — | — | EP | disclosed |
| EP-1263729-B1 | AZACYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF SEROTONIN RELATED DISEASES | ACADIA PHARM INC (US) | 2006-12-20 | — | — | EP | disclosed |