Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | FABP4 | P15090 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.39 |
| ▸ | IDH1 | O75874 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | CMA1 | P23946 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18009516 | 0.84 | SIRT6 (0.52) | SIRT6ALDH1A1HSD17B10MAPTFABP4 | |
| SCHEMBL16469334 | 0.83 | ALDH1A1 (0.49) | SIRT6ALDH1A1HSD17B10FABP4FABP5 | |
| SCHEMBL16469809 | 0.82 | SIRT6 (0.46) | SIRT6ALDH1A1HSD17B10MAPTFABP4 | |
| SCHEMBL18027982 | 0.82 | SIRT6 (0.46) | SIRT6ALDH1A1HSD17B10MAPTFABP4 | |
| SCHEMBL28624757 | 0.81 | SIRT6 (0.46) | SIRT6ALDH1A1HSD17B10MAPTFABP4 | |
| SCHEMBL16469956 | 0.79 | SIRT6 (0.43) | SIRT6ALDH1A1HSD17B10MAPTFABP4 | |
| SCHEMBL28127771 | 0.79 | SIRT6 (0.44) | SIRT6ALDH1A1HSD17B10MAPTFABP4 | |
| SCHEMBL18009513 | 0.78 | SIRT6 (0.42) | SIRT6ALDH1A1HSD17B10MAPTFABP4 | |
| SCHEMBL1498919 | 0.78 | ALDH1A1 (0.53) | ALDH1A1HSD17B10MAPTHPGDSMN1; SMN2 | |
| SCHEMBL18009535 | 0.77 | KAT6A (0.43) | SIRT6ALDH1A1MAPTFABP4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9533985-B2 | Sulfonamide derivative and medicinal use thereof | EA PHARMA CO., LTD. (JP) | 2017-01-03 | — | — | US | disclosed |
| US-9533985-B2 | Sulfonamide derivative and medicinal use thereof | EA PHARMA CO., LTD. (JP) | 2017-01-03 | — | — | US | disclosed |
| US-20150051395-A1 | SULFONAMIDE DERIVATIVE AND MEDICINAL USE THEREOF | AJINOMOTO CO., LTD. (JP) | 2015-02-19 | — | — | US | disclosed |
| US-20150051395-A1 | SULFONAMIDE DERIVATIVE AND MEDICINAL USE THEREOF | AJINOMOTO CO., LTD. (JP) | 2015-02-19 | — | — | US | disclosed |
| US-20150051395-A1 | SULFONAMIDE DERIVATIVE AND MEDICINAL USE THEREOF | AJINOMOTO CO., LTD. (JP) | 2015-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150051395-A1 | SULFONAMIDE DERIVATIVE AND MEDICINAL USE THEREOF | ITGB4, ITGA4, ITGA2 | SIRT6 2659/4885ALDH1A1 1151/4885HSD17B10 4530/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.