SCHEMBL16485208

SCHEMBL16485208

NCCCCCC(=O)NCC(=O)NCC(=O)NC(Cc1ccccc1)C(=O)O

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MMP2 P08253 1/20 0.60
ITGB3 P05106 8/20 0.58
ITGA2B P08514 8/20 0.58
FAAH O00519 2/20 0.56
F2 P00734 1/20 0.53
CHRNA1 P02708 1/20 0.51
CHRNG P07510 1/20 0.51
CHRNB1 P11230 1/20 0.51
CHRND Q07001 1/20 0.51
EPHX2 P34913 2/20 0.51
HDAC3 O15379 1/20 0.50
HDAC4 P56524 1/20 0.50
HDAC1 Q13547 1/20 0.50
HDAC7 Q8WUI4 1/20 0.50
HDAC2 Q92769 1/20 0.50
HDAC10 Q969S8 1/20 0.50
HDAC11 Q96DB2 1/20 0.50
HDAC8 Q9BY41 1/20 0.50
HDAC6 Q9UBN7 1/20 0.50
HDAC9 Q9UKV0 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16485202 0.90 CHRNB2 (0.56) MMP2ITGB3ITGA2BFAAHCHRNA1
SCHEMBL17128773 0.90 CHRNB2 (0.56) MMP2ITGB3ITGA2BFAAHCHRNA1
SCHEMBL11648896 0.90 ITGB3 (0.69) MMP2ITGB3ITGA2BFAAHEPHX2
SCHEMBL25874361 0.89 MMP2 (0.56) MMP2F2CHRNA1CHRNGCHRNB1
SCHEMBL16484811 0.88 MMP2 (0.55) MMP2ITGB3ITGA2BFAAHF2
SCHEMBL24982489 0.86 FAAH (0.69) ITGB3ITGA2BFAAHEPHX2HDAC3
SCHEMBL29630808 0.84 MMP2 (0.55) MMP2ITGB3ITGA2B
SCHEMBL10963364 0.84 ITGB3 (0.65) ITGB3ITGA2BFAAHEPHX2
SCHEMBL10960315 0.84 ITGB3 (0.65) ITGB3ITGA2BFAAHEPHX2
D-Phenylalanine SCHEMBL11649893 0.84 ITGB3 (0.62) MMP2ITGB3ITGA2BFAAHEPHX2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3101032-A1 ANTI-HER2 ANTIBODY-DRUG CONJUGATE DAIICHI SANKYO COMPANY, LIMITED (JP) 2016-12-07 EP disclosed
WO-2014057687-A1 ANTIBODY-DRUG CONJUGATE 第一三共株式会社 (JP) 2014-04-17 WO disclosed