Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.60 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.60 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.60 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | HSP90B1 | P14625 | 3/20 | 0.41 |
| ▸ | TRAP1 | Q12931 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16487461 | 0.83 | HSP90B1 (0.47) | HSP90AA1HSP90AB1ERBB2NUDT1LMNA | |
| SCHEMBL1861839 | 0.75 | ERBB2 (1.00) | HSP90AA1HSP90AB1ERBB2NUDT1LMNA | |
| SCHEMBL5132693 | 0.74 | LMNA (0.74) | HSP90AA1HSP90AB1ERBB2NUDT1LMNA | |
| SCHEMBL17060218 | 0.73 | NUDT1 (1.00) | HSP90AA1HSP90AB1ERBB2NUDT1LMNA | |
| SCHEMBL18776103 | 0.70 | NUDT1 (0.71) | HSP90AA1HSP90AB1ERBB2NUDT1LMNA | |
| SCHEMBL30109321 | 0.69 | NUDT1 (0.68) | HSP90AA1HSP90AB1ERBB2NUDT1LMNA | |
| SCHEMBL1059581 | 0.69 | NUDT1 (0.68) | HSP90AA1HSP90AB1ERBB2NUDT1LMNA | |
| SCHEMBL1858421 | 0.68 | HSP90AA1 (0.55) | HSP90AA1HSP90AB1ERBB2NUDT1LMNA | |
| SCHEMBL31709352 | 0.68 | HSP90AA1 (0.55) | HSP90AA1HSP90AB1ERBB2NUDT1LMNA | |
| SCHEMBL15080556 | 0.68 | HSP90AA1 (0.49) | HSP90AA1HSP90AB1ERBB2NUDT1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12600725-B2 | Selective GRP94 inhibitors and uses thereof | MEMORIAL SLOAN-KETTERING CANCER CENTER (US) | 2026-04-14 | — | — | US | disclosed |
| US-20230123747-A1 | SELECTIVE GRP94 INHIBITORS AND USES THEREOF | MEMORIAL SLOAN KETTERING CANCER CENTER (US) | 2023-04-20 | — | — | US | disclosed |
| US-11267816-B2 | Selective Grp94 inhibitors and uses thereof | MEMORIAL SLOAN-KETTERING CANCER CENTER (US) | 2022-03-08 | — | — | US | disclosed |
| CN-105899503-B | Selective GRP94 inhibitors and uses thereof | 纪念斯隆-凯特琳癌症中心 | 2020-08-18 | — | — | CN | disclosed |
| US-20200102312-A1 | SELECTIVE GRP94 INHIBITORS AND USES THEREOF | MEMORIAL SLOAN-KETTERING CANCER CENTER | 2020-04-02 | — | — | US | disclosed |
| US-10421758-B2 | Selective Grp94 inhibitors and uses thereof | MEMORIAL SLOAN-KETTERING CANCER CENTER (US) | 2019-09-24 | — | — | US | disclosed |
| CN-105899503-A | Selective GRP94 inhibitors and uses thereof | 纪念斯隆-凯特琳癌症中心 | 2016-08-24 | — | — | CN | disclosed |
| US-20160194328-A1 | SELECTIVE GRP94 INHIBITORS AND USES THEREOF | MEMORIAL SLOAN-KETTERING CANCER CENTER | 2016-07-07 | — | — | US | disclosed |
| EP-3033338-A2 | SELECTIVE GRP94 INHIBITORS AND USES THEREOF | Memorial Sloan-Kettering Cancer Center (US) | 2016-06-22 | — | — | EP | disclosed |
| WO-2015023976-A2 | SELECTIVE GRP94 INHIBITORS AND USES THEREOF | MEMORIAL SLOAN-KETTERING CANCER CENTER (US) | 2015-02-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160194328-A1 | SELECTIVE GRP94 INHIBITORS AND USES THEREOF | HSP90B1, HSP90AB2P, HSPE1 | HSP90AA1 9/4885HSP90AB1 4/4885ERBB2 725/4885 |
| US-10421758-B2 | Selective Grp94 inhibitors and uses thereof | HSP90B1, HSP90AB2P, HSPE1 | HSP90AA1 9/4885HSP90AB1 4/4885ERBB2 725/4885 |
| US-11267816-B2 | Selective Grp94 inhibitors and uses thereof | HSP90B1, HSP90AB2P, HSPE1 | HSP90AA1 9/4885HSP90AB1 4/4885ERBB2 725/4885 |
| US-12600725-B2 | Selective GRP94 inhibitors and uses thereof | GRPR, HSPB1, HSP90AB2P | HSP90AA1 14/4885HSP90AB1 8/4885ERBB2 402/4885 |
| US-20200102312-A1 | SELECTIVE GRP94 INHIBITORS AND USES THEREOF | HSP90B1, HSP90AB2P, HSPE1 | HSP90AA1 9/4885HSP90AB1 4/4885ERBB2 725/4885 |
| US-20230123747-A1 | SELECTIVE GRP94 INHIBITORS AND USES THEREOF | HSP90B1, HSP90AB2P, HSPE1 | HSP90AA1 9/4885HSP90AB1 4/4885ERBB2 725/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.