Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.74 |
| ▸ | TSHR | P16473 | 1/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.64 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.62 |
| ▸ | PI4KA | P42356 | 5/20 | 0.59 |
| ▸ | PI4K2B | Q8TCG2 | 5/20 | 0.59 |
| ▸ | PI4K2A | Q9BTU6 | 5/20 | 0.59 |
| ▸ | PI4KB | Q9UBF8 | 5/20 | 0.59 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.58 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.58 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.58 |
| ▸ | APEX1 | P27695 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5132695 | 0.79 | LMNA (0.48) | LMNATSHRALDH1A1NPSR1NUDT1 | |
| SCHEMBL17060218 | 0.77 | NUDT1 (1.00) | LMNATSHRALDH1A1NPSR1NUDT1 | |
| SCHEMBL9175738 | 0.74 | PI4KA (1.00) | LMNAALDH1A1NPSR1NUDT1PI4KA | |
| SCHEMBL18776103 | 0.74 | NUDT1 (0.71) | LMNATSHRALDH1A1NPSR1NUDT1 | |
| SCHEMBL1861839 | 0.74 | ERBB2 (1.00) | LMNATSHRALDH1A1NPSR1NUDT1 | |
| SCHEMBL16487462 | 0.74 | HSP90AA1 (0.60) | LMNATSHRALDH1A1NPSR1NUDT1 | |
| SCHEMBL29634267 | 0.73 | HTT (0.74) | LMNATSHRALDH1A1NPSR1NUDT1 | |
| SCHEMBL870861 | 0.71 | PI4KA (0.62) | LMNAALDH1A1NPSR1NUDT1PI4KA | |
| SCHEMBL843169 | 0.71 | ADORA2A (0.61) | LMNATSHRALDH1A1NPSR1NUDT1 | |
| SCHEMBL42335 | 0.71 | ADORA2A (0.61) | LMNATSHRALDH1A1NPSR1NUDT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1962863-A2 | ORALLY ACTIVE PURINE-BASED INHIBITORS OF HEAT SHOCK PROTEIN 90 | Conforma Therapeutics Corporation (US) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007075572-A2 | ORALLY ACTIVE PURINE-BASED INHIBITORS OF HEAT SHOCK PROTEIN 90 | CONFORMA THERAPEUTICS CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |
| US-20070129334-A1 | Orally Active Purine-Based Inhibitors of Heat Shock Protein 90 | CONFORMA THERAPEUTICS CORPORATION (US) | 2007-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070129334-A1 | Orally Active Purine-Based Inhibitors of Heat Shock Protein 90 | HSP90AB1, HSP90AA1, HSP90AB2P | LMNA 4007/4885TSHR 3978/4885ALDH1A1 2219/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.