Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | MAOA | P21397 | 3/20 | 0.47 |
| ▸ | MAOB | P27338 | 3/20 | 0.47 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | TDO2 | P48775 | 1/20 | 0.44 |
| ▸ | VNN1 | O95497 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16491996 | 0.81 | KDM4E (0.51) | KDM4EMAPTCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL1232930 | 0.80 | NPC1 (0.50) | KDM4ERAB9ANPC1MAOAMAOB | |
| SCHEMBL16491991 | 0.79 | KDM4E (0.49) | KDM4EMAPTRAB9ACYP1A2CYP3A4 | |
| SCHEMBL12279848 | 0.79 | AURKA (0.50) | KDM4EMAPTRAB9ACYP1A2CYP3A4 | |
| SCHEMBL2447775 | 0.78 | RAB9A (0.47) | KDM4EMAPTRAB9ACYP1A2CYP3A4 | |
| SCHEMBL16489562 | 0.78 | CTSB (0.57) | KDM4EMAPTCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL2397579 | 0.77 | GAA (0.60) | KDM4EMAPTRAB9ACYP1A2CYP3A4 | |
| SCHEMBL31201552 | 0.77 | MAOA (0.50) | KDM4EMAPTRAB9ACYP1A2CYP3A4 | |
| SCHEMBL16491982 | 0.75 | MAPT (0.68) | KDM4EMAPTRAB9ACYP1A2CYP3A4 | |
| SCHEMBL12887517 | 0.75 | MEN1 (0.53) | KDM4EMAPTRAB9ANPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9296748-B2 | Pyridinones | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2016-03-29 | — | — | US | disclosed |
| US-20150246919-A1 | PYRIDINONES | BOEHRINGER INGELHEIM INT (DE) | 2015-09-03 | — | — | US | disclosed |
| US-20150051208-A1 | PYRIDINONES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150051208-A1 | PYRIDINONES | MKI67, XDH, CDK6 | KDM4E 1683/4885MAPT 4084/4885RAB9A 3821/4885 |
| US-20150246919-A1 | PYRIDINONES | MKI67, XDH, CDK6 | KDM4E 1683/4885MAPT 4084/4885RAB9A 3821/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.