Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 2/20 | 0.46 |
| ▸ | PPARA | Q07869 | 2/20 | 0.46 |
| ▸ | METAP2 | P50579 | 1/20 | 0.44 |
| ▸ | METAP1 | P53582 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.40 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP12 | P39900 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | MMP14 | P50281 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MME | P08473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27597980 | 0.84 | METAP2 (0.49) | TDP1PPARGPPARAMETAP2METAP1 | |
| SCHEMBL9851494 | 0.79 | METAP2 (0.52) | TDP1METAP2METAP1CNR2TSHR | |
| Cadaverine Tartrate SCHEMBL3721240 | 0.78 | FFAR1 (0.56) | TDP1PPARGPPARATSHRSMN1; SMN2 | |
| SCHEMBL27514485 | 0.78 | TDP1 (0.55) | TDP1TSHRSMN1; SMN2MMP2MMP9 | |
| SCHEMBL10821305 | 0.76 | SMN1; SMN2 (0.52) | PPARGPPARATSHRSMN1; SMN2 | |
| SCHEMBL2854668 | 0.75 | PPARG (0.49) | PPARGPPARAMETAP2METAP1CNR2 | |
| SCHEMBL2852582 | 0.75 | PPARG (0.49) | PPARGPPARAMETAP2METAP1CNR2 | |
| SCHEMBL29722586 | 0.75 | LMNA (0.60) | TDP1PPARGPPARASMN1; SMN2MMP2 | |
| SCHEMBL8426058 | 0.74 | ALDH1A1 (0.55) | TDP1SMN1; SMN2KDM4E | |
| SCHEMBL6012976 | 0.74 | ALDH1A1 (0.55) | TDP1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7927613-B2 | Pharmaceutical co-crystal compositions | UNIVERSITY OF SOUTH FLORIDA (US) | 2011-04-19 | — | — | US | disclosed |
| US-7790905-B2 | Pharmaceutical propylene glycol solvate compositions | MCNEIL-PPC, INC. (US) | 2010-09-07 | — | — | US | disclosed |