Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAOA | P21397 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29053513 | 0.77 | ALDH1A1 (0.41) | LMNAKMT2ASMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL4442357 | 0.76 | LMNA (0.47) | LMNATSHRMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL27579779 | 0.76 | CFD (0.41) | LMNATSHRKDM4EHSD17B10L3MBTL1 | |
| SCHEMBL5740998 | 0.74 | TDP1 (0.39) | LMNAKMT2AL3MBTL1RAB9AALDH1A1 | |
| SCHEMBL3656329 | 0.74 | TDP1 (0.39) | LMNAKMT2ASMN1; SMN2L3MBTL1RAB9A | |
| SCHEMBL1189483 | 0.72 | ALDH1A1 (0.44) | LMNATSHRSMN1; SMN2L3MBTL1RAB9A | |
| SCHEMBL2852976 | 0.72 | LMNA (0.40) | LMNATSHRMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2850664 | 0.72 | LMNA (0.40) | LMNATSHRMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL29728538 | 0.71 | LMNA (0.57) | LMNATSHRMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL16965114 | 0.71 | LMNA (0.57) | LMNATSHRMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2240486-B1 | TRIAZOLIUM SALTS AS PAR1 INHIBITORS, THEIR MANUFACTURE AND THEIR APPLICATION AS MEDICINE | SANOFI SA (FR) | 2015-09-09 | — | — | EP | disclosed |
| EP-2240487-B1 | TRIAZOLOPYRIDAZINES AS PAR1 INHIBITORS, PRODUCTION THEREOF, AND USE AS MEDICAMENTS | SANOFI SA (FR) | 2011-12-14 | — | — | EP | disclosed |