Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 7/20 | 0.57 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.46 |
| ▸ | PRKG1 | Q13976 | 2/20 | 0.46 |
| ▸ | PRKACA | P17612 | 1/20 | 0.45 |
| ▸ | PRKACG | P22612 | 1/20 | 0.45 |
| ▸ | PRKACB | P22694 | 1/20 | 0.45 |
| ▸ | AKT1 | P31749 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16495617 | 0.87 | GABRA5 (0.44) | HPGDSKMT2AKDM1A | |
| SCHEMBL16495764 | 0.83 | HPGDS (0.68) | HPGDSALDH1A1KMT2ANPC1RAB9A | |
| SCHEMBL5053993 | 0.78 | HPGDS (0.75) | HPGDSALDH1A1KMT2ANPC1RAB9A | |
| SCHEMBL14190102 | 0.78 | HPGDS (0.75) | HPGDSROCK2PRKG1ALDH1A1KMT2A | |
| SCHEMBL15976440 | 0.77 | ALDH1A1 (0.48) | ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL12318678 | 0.77 | ALDH1A1 (0.48) | ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL16496157 | 0.76 | RAB9A (0.67) | HPGDSALDH1A1KMT2ANPC1RAB9A | |
| SCHEMBL16496317 | 0.75 | HPGDS (0.56) | HPGDSROCK2ALDH1A1TP53HPGD | |
| SCHEMBL16495998 | 0.75 | ROCK2 (0.66) | HPGDSROCK2PRKG1PRKACAPRKACG | |
| SCHEMBL16495758 | 0.75 | HPGDS (0.54) | HPGDSROCK2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110306597-A1 | Nicotinamide Derivatives | CRAWFORTH JAMES MICHAEL (GB) | 2011-12-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110306597-A1 | Nicotinamide Derivatives | NNT, NAMPT, NQO1 | HPGDS 1073/4885ROCK2 4683/4885PRKG1 3173/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.