Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADK | P55263 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | GALR3 | O60755 | 1/20 | 0.35 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | XDH | P47989 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 5/20 | 0.33 |
| ▸ | METTL3 | Q86U44 | 2/20 | 0.33 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | ATG7 | O95352 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13494110 | 0.91 | ADK (0.38) | ADKALDH1A1MAPTNPC1GALR3 | |
| SCHEMBL16496534 | 0.88 | ADK (0.36) | ADKALDH1A1MAPTNPC1GALR3 | |
| SCHEMBL14081712 | 0.87 | ADK (0.35) | ADKALDH1A1MAPTNPC1GALR3 | |
| SCHEMBL4014575 | 0.87 | ADK (0.35) | ADKALDH1A1MAPTNPC1GALR3 | |
| SCHEMBL16496977 | 0.85 | RET (0.36) | ADKRETLCKSRC | |
| SCHEMBL13494103 | 0.85 | ADK (0.34) | ADKXDHATG7PRKAB2PRKAG1 | |
| SCHEMBL4020234 | 0.83 | ABL1 (0.36) | ADKRETLCKSRC | |
| SCHEMBL14081718 | 0.82 | PRMT5 (0.45) | ADKMETTL3PRMT5 | |
| SCHEMBL4016824 | 0.82 | PRMT5 (0.45) | ADKMETTL3PRMT5 | |
| SCHEMBL4020116 | 0.80 | LMNA (0.32) | ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110306573-A1 | NUCLEOSIDE DERIVATIVES AS INHIBITORS OF VIRAL POLYMERASES | MERCK SHARP & DOHME CORP. | 2011-12-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110306573-A1 | NUCLEOSIDE DERIVATIVES AS INHIBITORS OF VIRAL POLYMERASES | POLR2E, POLR2H, POLRMT | ADK 762/4885ALDH1A1 921/4885MAPT 2709/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.