Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RPA1 | P27694 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16498279 | 0.87 | CHEK1 (0.44) | MAPTRAB9ANPC1POLBHTT | |
| SCHEMBL16498355 | 0.74 | CFTR (0.37) | TP53MAPTKDM4ERAB9ANPC1 | |
| SCHEMBL16498513 | 0.74 | TP53 (0.46) | TP53MAPTKDM4ELMNAALDH1A1 | |
| SCHEMBL16498847 | 0.74 | MAPT (0.36) | TP53MAPTKDM4ERAB9ANPC1 | |
| SCHEMBL16512790 | 0.73 | SLC5A1 (0.35) | TP53MAPTKDM4ERAB9ANPC1 | |
| SCHEMBL16512871 | 0.68 | ELANE (0.38) | MAPTKDM4ESMN1; SMN2POLBALDH1A1 | |
| SCHEMBL16498236 | 0.67 | CHEK1 (0.53) | TP53MAPTKDM4ERAB9ANPC1 | |
| SCHEMBL23675185 | 0.67 | HCAR3 (0.56) | TP53MAPTGFERLMNAHTT | |
| SCHEMBL16512866 | 0.66 | PTGER1 (0.46) | SMN1; SMN2LMNAALDH1A1RPA1 | |
| SCHEMBL16498450 | 0.65 | TP53 (0.45) | TP53MAPTSMN1; SMN2HTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011153588-A1 | VIRAL POLYMERASE INHIBITORS | BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) | 2011-12-15 | — | — | WO | disclosed |