Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 2/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11019913 | 0.85 | ADRB2 (0.41) | ADRB2HTR7CYP11B1CYP11B2ALDH1A1 | |
| SCHEMBL11020636 | 0.84 | TP53 (0.48) | ADRB2HTR7CYP11B1CYP11B2MAPK1 | |
| SCHEMBL11672601 | 0.81 | CYP1A2 (0.47) | HTR7ALDH1A1MAPK1RAB9AKDM4E | |
| SCHEMBL26153446 | 0.79 | ALDH1A1 (0.56) | ADRB2HTR7ALDH1A1RECQLMAPK1 | |
| SCHEMBL8303063 | 0.78 | PKM (0.44) | ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL8373048 | 0.77 | KCNH2 (0.53) | ALDH1A1RAB9AKDM4ESMN1; SMN2HTT | |
| SCHEMBL21540608 | 0.77 | ALDH1A1 (0.46) | ADRB2HTR7CYP11B1CYP11B2ALDH1A1 | |
| SCHEMBL8897316 | 0.77 | CYP11B1 (0.56) | ADRB2HTR7CYP11B1CYP11B2ALDH1A1 | |
| SCHEMBL11022941 | 0.77 | RAB9A (0.48) | ALDH1A1MAPK1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL17218114 | 0.76 | PTPN11 (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1698635-B1 | BENZIMIDAZOLE DERIVATIVES AND MEDICAL USES THEREOF | KISSEI PHARMACEUTICAL (JP) | 2011-12-14 | — | — | EP | disclosed |