SCHEMBL16502008

SCHEMBL16502008

Bc1cc(C(=O)Nc2c(C)cc(Cl)cc2C(=O)NC(C)C)n(-c2ncccc2Cl)n1

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDE4B Q07343 2/20 0.37
PDE4D Q08499 2/20 0.37
PDE4A P27815 2/20 0.37
PDE4C Q08493 1/20 0.37
MALT1 Q9UDY8 4/20 0.36
ALDH1A1 P00352 2/20 0.35
POLB P06746 1/20 0.35
MAPT P10636 1/20 0.35
PKM P14618 1/20 0.35
HPGD P15428 1/20 0.35
DHODH Q02127 1/20 0.35
RECQL P46063 1/20 0.35
CNR1 P21554 2/20 0.34
CNR2 P34972 1/20 0.34
EIF2S1 P05198 1/20 0.34
EIF2AK3 Q9NZJ5 1/20 0.34
CAPN1 P07384 1/20 0.33
CYP17A1 P05093 1/20 0.33
CYP1A2 P05177 1/20 0.33
F10 P00742 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14470626 0.91 DHODH (0.37) PDE4BPDE4DPDE4APDE4CMALT1
SCHEMBL782483 0.91 MALT1 (0.37) PDE4BPDE4DPDE4APDE4CMALT1
SCHEMBL12936147 0.91 KMT2A (0.38) MALT1MAPTHPGDDHODHRECQL
SCHEMBL12935740 0.90 MALT1 (0.38) PDE4BPDE4DPDE4APDE4CMALT1
SCHEMBL13650074 0.90 KCNH2 (0.36) PDE4BPDE4DPDE4APDE4CMALT1
SCHEMBL782232 0.90 DHODH (0.43) PDE4BPDE4DPDE4APDE4CMALT1
SCHEMBL16181542 0.87 MALT1 (0.35) PDE4BPDE4DPDE4APDE4CMALT1
SCHEMBL672741 0.87 PDE4B (0.36) PDE4BMALT1ALDH1A1MAPTDHODH
SCHEMBL14619128 0.87 MALT1 (0.35) PDE4BPDE4DPDE4APDE4CMALT1
SCHEMBL14435048 0.87 PDE4A (0.35) PDE4BPDE4DPDE4APDE4CMALT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2178859-B1 CONDENSED ANTHRANILAMIDE DERIVATIVES AS INSECTISIDES SYNGENTA PARTICIPATIONS AG (CH) 2011-12-21 EP disclosed