SCHEMBL782232

SCHEMBL782232

Cc1cc(Cl)cc(C(=O)NC(C)C)c1NC(=O)c1cc(Br)nn1-c1ncccc1Cl

nearest known ligand 0.82

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DHODH Q02127 3/20 0.43
PDE4A P27815 3/20 0.37
MALT1 Q9UDY8 3/20 0.36
RECQL P46063 1/20 0.35
S1PR1 P21453 1/20 0.35
S1PR3 Q99500 1/20 0.35
CNR1 P21554 2/20 0.34
KCNH2 Q12809 1/20 0.34
ALDH1A1 P00352 2/20 0.34
POLB P06746 1/20 0.34
MAPT P10636 1/20 0.34
PKM P14618 1/20 0.34
HPGD P15428 1/20 0.34
CNR2 P34972 1/20 0.34
EIF2S1 P05198 1/20 0.34
EIF2AK3 Q9NZJ5 1/20 0.34
CAPN1 P07384 1/20 0.33
PDE4B Q07343 1/20 0.33
PDE4C Q08493 1/20 0.33
PDE4D Q08499 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10140172 0.94 DHODH (0.38) DHODHPDE4AMALT1RECQLCNR1
SCHEMBL16622530 0.93 DHODH (0.42) DHODHPDE4AMALT1S1PR1S1PR3
SCHEMBL782222 0.93 DHODH (0.43) DHODHPDE4AMALT1S1PR1S1PR3
SCHEMBL14361041 0.93 DHODH (0.43) DHODHPDE4AMALT1S1PR1S1PR3
SCHEMBL782468 0.93 DHODH (0.41) DHODHPDE4ARECQLCNR1KCNH2
SCHEMBL31256508 0.93 DHODH (0.41) DHODHPDE4ARECQLCNR1KCNH2
SCHEMBL950662 0.91 DHODH (0.42) DHODHPDE4AMALT1S1PR1S1PR3
SCHEMBL12438370 0.91 DHODH (0.42) DHODHPDE4AMALT1S1PR1S1PR3
SCHEMBL10028768 0.91 DHODH (0.43) DHODHPDE4AMALT1S1PR1S1PR3
SCHEMBL12936147 0.91 KMT2A (0.38) DHODHMALT1RECQLCNR1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 265 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2910125-B1 INSECTICIDE COMPOSITIONS SUMITOMO CHEMICAL CO (JP) 2018-05-02 EP claimed
US-20160270396-A1 INSECTICIDE COMPOSITIONS SUMITOMO CHEMICAL CO (JP) 2016-09-22 US claimed
US-9408390-B2 Insecticide compositions SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2016-08-09 US claimed
US-20150282484-A1 INSECTICIDE COMPOSITIONS SUMITOMO CHEMICAL CO (JP) 2015-10-08 US claimed
EP-2910125-A1 Insecticide compositions Sumitomo Chemical Company, Limited (JP) 2015-08-26 EP claimed
EP-2474227-B1 Insecticide compositions SUMITOMO CHEMICAL CO (JP) 2015-04-15 EP claimed
EP-2484209-B1 Insecticide compositions SUMITOMO CHEMICAL CO (JP) 2015-04-01 EP claimed
EP-2484209-A1 Insecticide compositions Sumitomo Chemical Company, Limited (JP) 2012-08-08 EP claimed
EP-2474227-A1 Insecticide compositions Sumitomo Chemical Co., Ltd (JP) 2012-07-11 EP claimed
EP-1719409-B1 INSECTICIDE COMPOSITION SUMITOMO CHEMICAL CO (JP) 2012-07-11 EP claimed
US-20100227893-A1 INSECTICIDE COMPOSITIONS OHKAWARA YUICHI 2010-09-09 US claimed
US-20090076092-A1 METHOD FOR DISRUPTING REPRODUCTIVE PERFORMANCE OF ARTHROPODS ANNAN ISSAC BILLY 2009-03-19 US claimed
US-20070259787-A1 Insecticide Compositions SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2007-11-08 US claimed
EP-1719409-A1 INSECTICIDE COMPOSITION Sumitomo Chemical Takeda Agro Company, Limited (JP) 2006-11-08 EP claimed
US-10405548-B2 Fungicidal compositions SYNGENTA CROP PROTECTION LLC (US) 2019-09-10 US disclosed
EP-2547665-B1 INSECTICIDAL COMPOUNDS SYNGENTA PARTICIPATIONS AG (CH) 2018-07-04 EP disclosed
US-20180168158-A1 ANTHRANILAMIDE SEED TREATMENT COMPOSITIONS AND METHODS OF USE PIONEER HI-BRED INTERNATIONAL, INC. (US) 2018-06-21 US disclosed
US-20040198984-A1 1-(3-halopyrid-2-yl)-3-substituted-5-((2,4-substituted-6-aminocarbonyl)phenylaminocarbonyl) pyrazoles insecticides FMC CORPORATION 2004-10-07 US disclosed
EP-1416797-A1 ARTHROPODICIDAL ANTHRANILAMIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 2004-05-12 EP disclosed
WO-2003015519-A1 ARTHROPODICIDAL ANTHRANILAMIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 2003-02-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090076092-A1 METHOD FOR DISRUPTING REPRODUCTIVE PERFORMANCE OF ARTHROPODS NASP, CPS1, CYP11A1 DHODH 313/4885PDE4A 1144/4885MALT1 4280/4885
US-20100227893-A1 INSECTICIDE COMPOSITIONS DDT, NISCH, ITPR3 DHODH 830/4885PDE4A 387/4885MALT1 4735/4885
US-20180168158-A1 ANTHRANILAMIDE SEED TREATMENT COMPOSITIONS AND METHODS OF USE AADAC, ABL2, API5 DHODH 1157/4885PDE4A 2594/4885MALT1 2152/4885
US-20070259787-A1 Insecticide Compositions DDT, NISCH, ITPR3 DHODH 830/4885PDE4A 387/4885MALT1 4735/4885
US-20040198984-A1 1-(3-halopyrid-2-yl)-3-substituted-5-((2,4-substituted-6-aminocarbonyl)phenylaminocarbonyl) pyrazoles insecticides CYP4B1, CYP1B1, CYP2E1 DHODH 2558/4885PDE4A 1472/4885MALT1 3253/4885
US-10405548-B2 Fungicidal compositions PIK3C3, CYP51A1, CYP1B1 DHODH 874/4885PDE4A 504/4885MALT1 1035/4885
US-20160270396-A1 INSECTICIDE COMPOSITIONS DDT, NISCH, ITPR3 DHODH 830/4885PDE4A 387/4885MALT1 4735/4885
US-20150282484-A1 INSECTICIDE COMPOSITIONS DDT, NISCH, ITPR3 DHODH 830/4885PDE4A 387/4885MALT1 4735/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.