Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Fandofloxacin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.72 |
| ▸ | MEN1 | O00255 | 2/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.59 |
| ▸ | DRD3 | P35462 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.55 |
| ▸ | HPGD | P15428 | 4/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | RAD52 | P43351 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fandofloxacin SCHEMBL1650067 | 0.98 | LMNA (0.74) | LMNAMEN1KMT2AALDH1A1DRD3 | |
| Fandofloxacin SCHEMBL1230394 | 0.97 | LMNA (0.73) | LMNAMEN1KMT2AALDH1A1DRD3 | |
| SCHEMBL5195883 | 0.87 | KMT2A (0.58) | LMNAMEN1KMT2AALDH1A1DRD3 | |
| SCHEMBL8123703 | 0.87 | LMNA (0.73) | LMNAMEN1KMT2AALDH1A1DRD3 | |
| Hydrochloric Acid SCHEMBL8129182 | 0.86 | LMNA (0.75) | LMNAMEN1KMT2AALDH1A1DRD3 | |
| SCHEMBL8139807 | 0.86 | MEN1 (0.57) | LMNAMEN1KMT2AALDH1A1DRD3 | |
| Difloxacin SCHEMBL27973383 | 0.86 | LMNA (0.96) | LMNAMEN1KMT2AALDH1A1DRD3 | |
| Difloxacin SCHEMBL148765 | 0.84 | LMNA (1.00) | LMNAMEN1KMT2AALDH1A1DRD3 | |
| SCHEMBL10666385 | 0.84 | LMNA (0.81) | LMNAMEN1KMT2AALDH1A1DRD3 | |
| Difloxacin SCHEMBL29695838 | 0.84 | LMNA (1.00) | LMNAMEN1KMT2AALDH1A1DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7927613-B2 | Pharmaceutical co-crystal compositions | UNIVERSITY OF SOUTH FLORIDA (US) | 2011-04-19 | — | — | US | disclosed |