Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | MAOA | P21397 | 12/20 | 0.43 |
| ▸ | MAOB | P27338 | 11/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16520535 | 0.83 | CYP3A4 (0.47) | CYP3A4MAPTKDM4ENR3C1PGR | |
| SCHEMBL17771359 | 0.81 | MAOA (0.44) | CYP3A4MAOAMAOBMAPTKDM4E | |
| SCHEMBL6202478 | 0.73 | CYP3A4 (0.67) | CYP3A4MAOAMAOBMAPTKDM4E | |
| SCHEMBL25252214 | 0.69 | CYP3A4 (0.42) | CYP3A4MAOAMAOBMAPTKDM4E | |
| SCHEMBL18185318 | 0.69 | KCNJ1 (0.54) | MAOAMAOBMAPTKDM4EROCK2 | |
| SCHEMBL25218002 | 0.69 | MAOA (0.40) | CYP3A4MAOAMAOBMAPTKDM4E | |
| SCHEMBL16504461 | 0.68 | KMT2A (0.39) | KDM4EMTNR1A | |
| Metameconine SCHEMBL800990 | 0.68 | CYP3A4 (1.00) | CYP3A4MAOAMAOBMAPTKDM4E | |
| SCHEMBL25421184 | 0.68 | KCNJ1 (0.52) | MAOAMAOBMAPTKDM4ENR3C1 | |
| SCHEMBL27113318 | 0.66 | PDK2 (0.55) | MAOAMAOBMAPTNR3C1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9963427-B2 | Dithiol mucolytic agents | PARION SCIENCES, INC. (US) | 2018-05-08 | — | — | US | disclosed |
| US-20160318861-A1 | NOVEL PRODRUGS OF DITHIOL MUCOLYTIC AGENTS | PARION SCIENCES, INC. (US) | 2016-11-03 | — | — | US | disclosed |
| US-20160194278-A1 | DITHIOL MUCOLYTIC AGENTS | PARION SCIENCES, INC. (US) | 2016-07-07 | — | — | US | disclosed |
| EP-3035923-A2 | DITHIOL MUCOLYTIC AGENTS | Parion Sciences, Inc. (US) | 2016-06-29 | — | — | EP | disclosed |
| US-9346753-B2 | Dithiol mucolytic agents | PARION SCIENCES, INC. (US) | 2016-05-24 | — | — | US | disclosed |
| WO-2015026601-A2 | DITHIOL MUCOLYTIC AGENTS | JOHNSON MICHAEL R (US) | 2015-02-26 | — | — | WO | disclosed |
| US-20150056305-A1 | DITHIOL MUCOLYTIC AGENTS | PARION SCIENCES, INC. (US) | 2015-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160194278-A1 | DITHIOL MUCOLYTIC AGENTS | MUC1, DNASE1, MMP8 | CYP3A4 3760/4885MAOA 975/4885MAOB 1212/4885 |
| US-20150056305-A1 | DITHIOL MUCOLYTIC AGENTS | MUC1, DNASE1, MMP8 | CYP3A4 3760/4885MAOA 975/4885MAOB 1212/4885 |
| US-20160318861-A1 | NOVEL PRODRUGS OF DITHIOL MUCOLYTIC AGENTS | MUC1, MGMT, ESD | CYP3A4 1700/4885MAOA 1361/4885MAOB 950/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.