Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | AR | P10275 | 5/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA4 | P22748 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
| ▸ | NAAA | Q02083 | 1/20 | 0.43 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16506561 | 0.80 | MEN1 (0.44) | ALDH1A1MAPK1HTTL3MBTL1POLB | |
| SCHEMBL3721302 | 0.76 | AR (0.44) | ARNAAASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2185557 | 0.76 | NAAA (0.42) | ALDH1A1HTTPOLBGAACA12 | |
| SCHEMBL3722003 | 0.74 | SLC22A12 (0.46) | ARPOLBGAAHPGDSSLC6A2 | |
| SCHEMBL920146 | 0.74 | L3MBTL1 (0.70) | ALDH1A1MAPK1HTTL3MBTL1AR | |
| SCHEMBL16506568 | 0.72 | LPAR1 (0.56) | ALDH1A1MAPK1HTTL3MBTL1POLB | |
| SCHEMBL3627857 | 0.71 | HTT (1.00) | ALDH1A1MAPK1HTTL3MBTL1AR | |
| SCHEMBL11544969 | 0.71 | L3MBTL1 (0.60) | ALDH1A1MAPK1HTTL3MBTL1POLB | |
| SCHEMBL3719152 | 0.71 | AR (0.48) | ARSLC22A12 | |
| SCHEMBL791852 | 0.69 | HTT (0.86) | ALDH1A1MAPK1HTTL3MBTL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190010129-A1 | Amide derivatives as lysophosphatidic acid receptor antagonists | TAKEDA PHARMACEUTICAL COMPANY LIMITED | 2019-01-10 | — | — | US | disclosed |
| US-10100018-B2 | Amide derivatives as lysophosphatidic acid receptor antagonists | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-10-16 | — | — | US | disclosed |
| US-9464060-B2 | Compounds | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-10-11 | — | — | US | disclosed |
| US-20160207880-A1 | AMIDE DERIVATIVES AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-07-21 | — | — | US | disclosed |
| EP-3036215-A1 | AMIDE DERIVATIVES AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Takeda Pharmaceutical Company Limited (JP) | 2016-06-29 | — | — | EP | disclosed |
| CN-105473548-A | Amide derivatives as lysophosphatidic acid receptor antagonists | TAKEDA PHARMACEUTICALS CO | 2016-04-06 | — | — | CN | disclosed |
| WO-2015025164-A1 | AMIDE DERIVATIVES AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2015-02-26 | — | — | WO | disclosed |
| US-20150057298-A1 | NOVEL COMPOUNDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED | 2015-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10100018-B2 | Amide derivatives as lysophosphatidic acid receptor antagonists | LPAR1, LPAR2, LPAR3 | ALDH1A1 4052/4885MAPK1 2604/4885HTT 4652/4885 |
| US-20190010129-A1 | Amide derivatives as lysophosphatidic acid receptor antagonists | LPAR1, LPAR2, LPAR3 | ALDH1A1 3740/4885MAPK1 2514/4885HTT 4760/4885 |
| US-20160207880-A1 | AMIDE DERIVATIVES AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | LPAR1, LPAR2, LPAR3 | ALDH1A1 4052/4885MAPK1 2604/4885HTT 4652/4885 |
| US-20150057298-A1 | NOVEL COMPOUNDS | F12, C1R, CHRM1 | ALDH1A1 1598/4885MAPK1 3857/4885HTT 2974/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.