Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Tolpropamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 5/20 | 0.57 |
| ▸ | SLC6A2 known ✓ | P23975 | 5/20 | 0.57 |
| ▸ | CHRM1 known ✓ | P11229 | 4/20 | 0.50 |
| ▸ | SLC6A3 known ✓ | Q01959 | 4/20 | 0.50 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.50 |
| ▸ | HRH1 | P35367 | 7/20 | 0.75 |
| ▸ | HTR2A | P28223 | 6/20 | 0.75 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.57 |
| ▸ | SCN1A | P35498 | 3/20 | 0.57 |
| ▸ | SCN2A | Q99250 | 3/20 | 0.57 |
| ▸ | SCN3A | Q9NY46 | 3/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.50 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.50 |
| ▸ | THPO | P40225 | 2/20 | 0.50 |
| ▸ | DRD1 | P21728 | 2/20 | 0.50 |
| ▸ | HTR2C | P28335 | 2/20 | 0.50 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tolpropamine SCHEMBL29300 | 0.96 | HRH1 (0.81) | HRH1HTR2ACHRM2SLC6A2SLC6A4 | |
| Tolpropamine SCHEMBL4193587 | 0.95 | HRH1 (0.78) | HRH1HTR2ACHRM2SLC6A2SLC6A4 | |
| SCHEMBL1802493 | 0.87 | HRH1 (1.00) | HRH1HTR2ACHRM2SLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL11383046 | 0.85 | HRH1 (0.95) | HRH1HTR2ACHRM2SLC6A2SLC6A4 | |
| SCHEMBL14198390 | 0.81 | CHRM2 (0.83) | HRH1HTR2ACHRM2SLC6A2SLC6A4 | |
| SCHEMBL29723649 | 0.80 | CNR1 (0.56) | HRH1HTR2ACHRM2SLC6A2SLC6A4 | |
| SCHEMBL10778672 | 0.80 | HTR2A (0.78) | HRH1HTR2ACHRM2SLC6A2SLC6A4 | |
| SCHEMBL29101424 | 0.80 | HRH1 (0.78) | HRH1HTR2ACHRM2SLC6A2SLC6A4 | |
| SCHEMBL11382183 | 0.77 | HRH1 (0.72) | HRH1HTR2ACHRM2SLC6A2SLC6A4 | |
| SCHEMBL10429837 | 0.75 | HTR2A (0.47) | HRH1HTR2AUTS2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7927613-B2 | Pharmaceutical co-crystal compositions | UNIVERSITY OF SOUTH FLORIDA (US) | 2011-04-19 | — | — | US | disclosed |
| US-7790905-B2 | Pharmaceutical propylene glycol solvate compositions | MCNEIL-PPC, INC. (US) | 2010-09-07 | — | — | US | disclosed |