Tolpropamine

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	Tolpropamine SCHEMBL29300	0.98	HRH1 (0.81)	HRH1HTR2ACHRM2SLC6A2SLC6A4
	Tolpropamine SCHEMBL1651656	0.95	HRH1 (0.75)	HRH1HTR2ACHRM2SLC6A2SLC6A4
	Hydrochloric Acid SCHEMBL11383046	0.90	HRH1 (0.95)	HRH1HTR2ACHRM2SLC6A2SLC6A4
	SCHEMBL1802493	0.88	HRH1 (1.00)	HRH1HTR2ACHRM2SLC6A2SLC6A4
	SCHEMBL29723649	0.82	CNR1 (0.56)	HRH1HTR2ACHRM2SLC6A2SLC6A4
	SCHEMBL10778672	0.81	HTR2A (0.78)	HRH1HTR2ACHRM2SLC6A2SLC6A4
	SCHEMBL14198390	0.79	CHRM2 (0.83)	HRH1HTR2ACHRM2SLC6A2SLC6A4
	SCHEMBL11382183	0.79	HRH1 (0.72)	HRH1HTR2ACHRM2SLC6A2SLC6A4
	Hydrochloric Acid SCHEMBL11374749	0.79	HTR2A (0.96)	HRH1HTR2ACHRM2SLC6A2SLC6A4
	SCHEMBL29101424	0.78	HRH1 (0.78)	HRH1HTR2ACHRM2SLC6A2SLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.