Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR5A | P47898 | 3/20 | 0.49 |
| ▸ | PNMT | P11086 | 6/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | HTR2B | P41595 | 2/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16518198 | 0.91 | HTR5A (0.48) | HTR5APNMTHTR2AHTR2CHTR2B | |
| SCHEMBL16518011 | 0.81 | HTR5A (0.47) | HTR5AHTR2AHTR2CHTR2B | |
| SCHEMBL16518188 | 0.78 | PNMT (0.41) | HTR5APNMTHTR2AHTR2CHTR2B | |
| SCHEMBL16518154 | 0.75 | NFATC1 (0.38) | PNMTHTR2AHTR2CHTR2BSOS1 | |
| SCHEMBL16518185 | 0.75 | HTR2C (0.37) | HTR5APNMTHTR2AHTR2CHTR2B | |
| SCHEMBL16518157 | 0.73 | PNMT (0.45) | PNMTHTR2AHTR2CHTR2BADRA2A | |
| SCHEMBL16518179 | 0.72 | HTR2C (0.35) | HTR5APNMTHTR2AHTR2CHTR2B | |
| SCHEMBL16518156 | 0.71 | PNMT (0.46) | HTR5APNMTHTR2AHTR2CHTR2B | |
| SCHEMBL16518170 | 0.71 | HTR5A (0.41) | HTR5APNMTHTR2AHTR2CHTR2B | |
| SCHEMBL16518183 | 0.71 | HTR5A (0.49) | HTR5AHTR2AHTR2CHTR2BHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2671869-B1 | TETRAHYDROISOQUINOLINE DERIVATIVE | ASTELLAS PHARMA INC (JP) | 2015-11-04 | — | — | EP | disclosed |
| US-8962612-B2 | Tetrahydroisoquinoline derivative | ASTELLAS PHARMA INC. (JP) | 2015-02-24 | — | — | US | disclosed |
| US-8962612-B2 | Tetrahydroisoquinoline derivative | ASTELLAS PHARMA INC. (JP) | 2015-02-24 | — | — | US | disclosed |