Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 5/20 | 0.45 |
| ▸ | HTR7 | P34969 | 4/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | PRCP | P42785 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16518139 | 0.86 | PNMT (0.53) | PNMTHTR7HTR2AHTR2CHTR2B | |
| SCHEMBL16518155 | 0.86 | HTR7 (0.47) | PNMTHTR7HTR2AHTR2CHTR2B | |
| SCHEMBL16518156 | 0.82 | PNMT (0.46) | PNMTHTR2AHTR2CHTR2BPRCP | |
| SCHEMBL16518148 | 0.82 | PNMT (0.45) | PNMTHTR7HTR2AHTR2CHTR2B | |
| SCHEMBL16518181 | 0.82 | HTR7 (0.43) | HTR7HTR2AHTR2CHTR2BPRCP | |
| SCHEMBL16518154 | 0.80 | NFATC1 (0.38) | PNMTHTR2AHTR2CHTR2BADRA2A | |
| SCHEMBL11758648 | 0.77 | TAAR1 (0.50) | PNMTHTR7PRCPTAAR1ALDH1A1 | |
| SCHEMBL16518153 | 0.76 | HTR5A (0.41) | PNMTHTR7HTR2AHTR2CHTR2B | |
| SCHEMBL14677593 | 0.76 | PNMT (0.72) | PNMTHTR7HTR2CPRCPTAAR1 | |
| SCHEMBL16518170 | 0.76 | HTR5A (0.41) | PNMTHTR7HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2671869-B1 | TETRAHYDROISOQUINOLINE DERIVATIVE | ASTELLAS PHARMA INC (JP) | 2015-11-04 | — | — | EP | disclosed |
| US-8962612-B2 | Tetrahydroisoquinoline derivative | ASTELLAS PHARMA INC. (JP) | 2015-02-24 | — | — | US | disclosed |
| US-8962612-B2 | Tetrahydroisoquinoline derivative | ASTELLAS PHARMA INC. (JP) | 2015-02-24 | — | — | US | disclosed |