Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.48 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.40 |
| ▸ | PLA2G6 | O60733 | 4/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | BLM | P54132 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | GMNN | O75496 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16536751 | 1.00 | MTNR1A (0.48) | MTNR1AIDO1KLK5HPGDHSD17B10 | |
| SCHEMBL657069 | 0.86 | MTNR1A (0.57) | MTNR1AIDO1HPGDHSD17B10KDM4E | |
| SCHEMBL16547292 | 0.75 | MTNR1A (0.42) | MTNR1AIDO1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL16535401 | 0.75 | CTRB1 (0.55) | HPGDHSD17B10KDM4ESIRT1ALDH1A1 | |
| SCHEMBL16535402 | 0.75 | CTRB1 (0.55) | HPGDHSD17B10KDM4ESIRT1ALDH1A1 | |
| SCHEMBL16538091 | 0.74 | CTRB1 (0.41) | HPGDHSD17B10KDM4EALDH1A1DRD2 | |
| SCHEMBL16538092 | 0.74 | CTRB1 (0.41) | HPGDHSD17B10KDM4EALDH1A1DRD2 | |
| SCHEMBL562292 | 0.72 | MTNR1A (0.58) | MTNR1AIDO1HPGDHSD17B10KDM4E | |
| SCHEMBL18827390 | 0.72 | CREBBP (0.46) | HPGDSIRT1ALDH1A1MAPT | |
| SCHEMBL28764771 | 0.71 | GSK3B (0.48) | MTNR1AIDO1GSK3BADKKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9643947-B2 | 7-membered fused heterocycles and methods of their synthesis | NORTHWESTERN UNIVERSITY (US) | 2017-05-09 | — | — | US | disclosed |
| US-9643947-B2 | 7-membered fused heterocycles and methods of their synthesis | NORTHWESTERN UNIVERSITY (US) | 2017-05-09 | — | — | US | disclosed |
| US-9643947-B2 | 7-membered fused heterocycles and methods of their synthesis | NORTHWESTERN UNIVERSITY (US) | 2017-05-09 | — | — | US | disclosed |
| US-20150065703-A1 | 7-MEMBERED FUSED HETEROCYCLES AND METHODS OF THEIR SYNTHESIS | NORTHWESTERN UNIVERSITY (US) | 2015-03-05 | — | — | US | disclosed |
| US-20150065703-A1 | 7-MEMBERED FUSED HETEROCYCLES AND METHODS OF THEIR SYNTHESIS | NORTHWESTERN UNIVERSITY (US) | 2015-03-05 | — | — | US | disclosed |
| US-20150065703-A1 | 7-MEMBERED FUSED HETEROCYCLES AND METHODS OF THEIR SYNTHESIS | NORTHWESTERN UNIVERSITY (US) | 2015-03-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150065703-A1 | 7-MEMBERED FUSED HETEROCYCLES AND METHODS OF THEIR SYNTHESIS | HTR7, CDK7, CBX7 | MTNR1A 1952/4885IDO1 2054/4885KLK5 1768/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.